摘要
Abstract
Objective To observe the effects of Traditional Chinese Medical remedy of strengthening the spleen, tonifying the kidney and detoxification combined with Western Medicine on peripheral blood cytokines IL-2 and IFN-γ in patients with chronic HBV infection. Methods 120 patients with chronic HBV infection were randomly divided into control group, strengthening the spleen group, tonifying the kidney group and detoxification group, with 30 patients in each group. The control group was treated with lamivudine. The strengthening the spleen group was given lamivudine and Sijunzi decoction. The tonifying the kidney group was given lamivudine and Liuwei Dihuang pills. The detoxification group was given lamivudine and Ganlu Xiaodu pills. The treatment course was 1 year. The levels of serum IL-2 and IFN-γ were measured before and after treatments. Results Before treatments, the differences of serum cytokine levels among 4 groups were not statistically significant (R>0.05). After treatment, the levels of serum IL-2 and IFN-γ increased significantly in 4 groups (P<0.05). Compared with control group, the levels of serum IL-2 and IFN-γ in strengthening the spleen group and tonifying the kidney group increased significantly after treatments (P<0.05,P<0.01), and the changes were most obvious in tonifying the kidney group (with statistic differences)(P<0.05). There was no significant difference between detoxification group and strengthening the spleen group after treatments (P>0.05). Conclusion The method of tonifying the kidney is better than strengthening the spleen and detoxification methods to improve the imbalance of cytokine IL-2 and IFN-γ in patients with chronic HBV infection.关键词
慢性乙型肝炎病毒感染/白介素-2/干扰素-γ/健脾法/补肾法/解毒法Key words
Chronic HBV infection/ IL-2/ IFN-γ/ the method of strengthening the spleen/ the method of tonifying the kidney/ the method of detoxification分类
医药卫生
