湖南中医药大学学报2012，Vol.32Issue(7)：67-71,5.DOI:10.3969/j.issn.1674-070X.2012.07.019.067.05
子午流注蜂针对强直性脊柱炎的疗效及机制研究
Effects and mechanism of bee-venom-acupuncture based on Midnight-Noon Ebb-Flow doctrine on ankylosing spondylitis
摘要
Abstract
Objective To observe the effects and safety of bee-venom-acupuncture based on Midnight-Noon Ebb-Flow doctrine on ankylosing spondylitis (AS), and its impacts on IL-6, TNF-α and sex hormone levels, and to explore its mechanisms. Methods 120 AS patients were randomly divided into 3 groups: 40 patients in treatment group were treated with bee-venom-acupuncture based on Midnight -Noon Ebb -Flow doctrine and syndrome differentiation; 40 patients in control group A were treated with bee-acupuncture based on syndrome differentiation; and 40 patients in the control group B were treated with sulfasalazine(SSZ) and diclofenac sodium. A treat- ment course was 4 weeks. Before and after 3 courses, indexes were observed and recorded, such as Bath AS disease activity index (BAS-DAI), Bath AS functional index (BASFI), duration of morning stiffness, likert' 4-grade score of whole body pain and spinal pain, evaluation by doctors and patients, the erythrosedi mentation (ESR), C-reactive protein (CRP), and the levels of IL-6, TNF-α and sex hormones. Adverse effects of medicines were also observed. Results The total effective rate was 82.5%, 72.5% and 70.0% in treatment group, control group A and control group B respectively; the statistic differences were significant (P<0.05). In 3 groups, indexes of BASDAI, BASFI, duration of morning stiffness, Likert' 4-grade score of whole body pain and spinal pain, evaluation by doctors and patients were improved obviously after treatments; ESR, CRP, IL-6, TNF-α and Testosterone were significantly decreased after treatments; the differences had statistic significance (P<0.05). Compared with the date of controls, the treatment group also showed better results after treatments; the differences between treatment group and control groups had significance (P<0.05). In 3 groups, Estradiol and Follicle-stimulating hormones were increased after treatments; Prolactin, Progesterone and Luteinizing hormones were decreased after treatments; but before and after treatments there was no significant difference (P>0.05). The incidence rate of adverse effects in treatment group was 10%, while that in the control group A and B was 12% and 30% respectively. Conclusion Bee-venom-acupuncture based on Midnight-Noon Ebb-Flow doctrine presents significant efficacy on AS with less adverse effects. The mechanism may be related to inhibition of IL-6, TNF-α and Testosterone production.关键词
强直性脊柱炎/子午流注/蜂针治疗/白细胞介素/肿瘤坏死因子-α/性激素/临床观察Key words
ankylosing spondylitis/ Midnight-noon Ebb-flow doctrine/ bee-venom-acupuncture/ IL-6/ TNF-α/ sex hormones/ clinical observation分类
医药卫生引用本文复制引用
温伟强,黄胜光,陈辉,谭宁,周汝云,朱辉军..子午流注蜂针对强直性脊柱炎的疗效及机制研究[J].湖南中医药大学学报,2012,32(7):67-71,5.基金项目
深圳市科技计划资助项目(201003264). （201003264）
