四川大学学报（医学版）2012，Vol.43Issue(3)：442-446,5.
糖尿病肾病腹膜透析患者的临床特点和预后
A Comparison of Clinical Characteristics and Survival Between Diabetic Nephropathy Patients and Non-diabetic Nephropathy Patients Undergoing Peritoneal Dialysis
钟慧 1刘芳 1付平 1沙朝晖 1唐晓红 1秦敏 1周雪丽 1任英1
作者信息
- 1. 四川大学华西医院肾脏内科,成都610041
- 折叠
摘要
Abstract
Objective To investigate clinical characteristics and survival of diabetic patients with end-stage renal disease on peritoneal dialysis (PD). Methods The clinical data were collected from the patients who initiated PD in our PD Center from Jan> 2009 through Aug. 2011. The patients were divided into diabetic group and non-diabetic group, the survival of patients and risk factors of death were analyzed and compared between the two groups by using Kaplan-Meier and Cox regression analysis. Results There were 460 PD patients included in this study, 64 (13. 9%) of them were diabetic and 396(86. 1%) were non-diabetic. Compared with non-diabetic PD patients, the PD patients with diabetes were older [(63± 13) yr. vs (45± 16) yr. , P<0. 001], while had higher level of high sensitive C reaction protein (hsCRP), lower levels of serum albumin and pre-albumin, as well as lower levels of triglyceridc and nPCR. There was no statistical difference in serum concentrations of hemoglobin, parathyroid hormone, cholesterol, and Kt/V and residual renal function between the two groups. The survival rates of PD patients with diabetics versus non-diabetics were 73. 3% versus 90. 7% at 1 year, and 61.8% vs 82. 5%(P<0. 05) at 2 years. Mean survival time of diabetic PD patients (24. 6 months) was significantly inferior to non-diabetic PD patients (30. 1 months) (P<0. 05). The relative risk of mortality in diabetic PD patients was 2. 449 times of that in non-diabetic patients. Multivariate Cox regression analysis, indicated that serum albumin level and patient age were significant risk factors for mortality. Conclusion Diabetic patients tended to be elderly, malnutrition and microinflammation at the beginning of PD. The survival of diabetic PD patients is inferior to non-diabetic PD patients on CAPD. Age and albumin level were risk factors for mortality in PD patients.关键词
糖尿病肾病/腹膜透析/预后Key words
Diabetes nephropathy/ Peritoneal dialysis/ Survival引用本文复制引用
钟慧,刘芳,付平,沙朝晖,唐晓红,秦敏,周雪丽,任英..糖尿病肾病腹膜透析患者的临床特点和预后[J].四川大学学报（医学版）,2012,43(3):442-446,5.
