四川大学学报（医学版）2012，Vol.43Issue(4)：540-542,546,4.
川芎嗪预处理对大鼠肝缺血再灌注损伤能量代谢的保护作用
Protective Effect of Ligustrazine Preconditioning on Hepatic Energy Metabolism in lschemía/Reperfusion Injury of Rat Liver
摘要
Abstract
Objective Objective To investigate the protective effects of Ligustrazine preconditioning against hepatic ischemia/reperfusion injury (IR1) in rats. Methods Fifty male Wistar rats were randomly allocated into 3 groups: sham operation group, in which animals underwent laparotomy, experimental group and control group in which were treated with 70% IRI of the liver, especially, the animals in experimental group was given intraperitoneal injection of 2 mL Ligustrazine per day for 3 days before operation. After the operation, liver tissues were harvested at 1 h, 6 h, 24 h and 72 h for the study of histomorphological change, the respiratory control ratio (RCR) and phosphorus: oxygen ratio (P/O) of hepatocytes mitochondria, and the contents of adenosine triphosphate (ATP) of liver tissue. Results ①The damage hepatic tissue in experimental group was slighter than that in control group at each corresponding time-point after operation.② The RCR and P/O ratio at each corresponding time-point were higher in experimental group than those in control group (P<0. 05), and all of the two groups recovered after 72 h.③ The ATP concentration in experimental group also was higher than that in control group at each corresponding time-point, and recovered faster than control group. Conclusion The current results show that Ligustrazine preconditioning may improve energy metabolism of rat liver in ischemia reperfusion injury.关键词
川芎嗪/预处理/肝缺血再灌注损伤/能量代谢Key words
Ligustrazine/Preconditioning/Liver ischemia/reperfusion/Energy metabolism引用本文复制引用
骆助林,田伏洲,汤礼军,汪涛,任建东,闫洪涛,黄竹,王华..川芎嗪预处理对大鼠肝缺血再灌注损伤能量代谢的保护作用[J].四川大学学报（医学版）,2012,43(4):540-542,546,4.基金项目
全军医学科学技术研究"十一五"课题(No.08Z012)资助 （No.08Z012）
