四川大学学报（医学版）2012，Vol.43Issue(4)：543-546,4.
盐酸戊乙奎醚对体外循环机体炎症反应的影响
Effect of Penehyclidine Hydrochloride in Systemic Inflammatory Response Syndrome Caused by Cardiopulmonary Bypass
舒丽娟 1魏新川1
作者信息
- 1. 四川大学华西医院麻醉科,成都610041
- 折叠
摘要
Abstract
Objective To investigate whether Penehyclidine hydrochloride has effect on the inflammatory process and leukocytes in cardiac surgery patients undergoing cardiopulmonary bypass. Methods 40 rheumatic heart disease patients undergoing CPB were randomly divided into Penehyclidine hydrochloride (P) group and control (C) group (20 patients in each group). In group P, intravenous drip of 0. 01 mg/kg of Penehyclidine hydrochloride injection was given before anesthesia, and 0. 015 mg/kg of Penehyclidine hydrochloride was added into initial volume of CPB. While in control group, 0. 9% NaCl solution was given instead of injection as a placebo. Blood samples were taken before anesthesia (TO). 30 min after CPB (T1), 10 min after aortic off-clamping (T2) and 2 hours when CPB was over (T3). Interleukin-6 (IL-6), tumornecross alpha (TNF-α) levels were detected by ELISA. The morbility of pneumonia and SIRS caused by CPB was also evaluated. Results At T2 and T3, the IL-6 level was higher than TO and T1 both in group C and group P (P<0. 05). At T2 and T3, the IL-6 level in group C was higher than that of group P (P<0. 05). The TNF-α level at T3 was lower than at T1 and T2 in group P (P< 0.05). There was no significant difference between group P and group C at each time point (P>0. 05). The morbility of pneumonia and SIRS was higher in group C (P<0. 05). Conclusion Penehyclidine hydrochloride can decrease the levels of proinflamnlatory cytokines in plasma and therefore attenuate the morbility of pneumonia and SIRS caused by CPB.关键词
盐酸戊乙奎醚/体外循环/炎症反应/细胞因子Key words
Penehyclidine hydrochloride/Cardiopulmonary bypass/ Systemic inflammatory response syndrome/Cytokines引用本文复制引用
舒丽娟,魏新川..盐酸戊乙奎醚对体外循环机体炎症反应的影响[J].四川大学学报（医学版）,2012,43(4):543-546,4.
