四川大学学报（医学版）2012，Vol.43Issue(4)：601-604,4.
钆布醇和钆贝葡胺在磁共振成像诊断肺癌脑转移中的对照研究
Comparison of the Efficacy of Gadobutrol and Multihance in Contrast-enhanced MRI for Diagnosis of Brain Metastasis in Lung Cancer
李真林 1陈宪 1夏春潮 1孙家瑜 1李昌宪 1唐鹤菡 1宋彬1
作者信息
- 1. 四川大学华西医院放射科,成都610041
- 折叠
摘要
Abstract
Objective To investigate the diagnostic efficacy of gadobutrol for assessing brain metastases in lung cancer patients in comparison with multihance. Methods 21 patients with lung cancer suspected of brain metastasis were enrolled in this study. All patients underwent twice MRI scans on a 3. 0T MRI scanner (Siemens MAGENETOM Trio) with 8-channel head coil, first with 0. 5 mol/L multihance and then with 1. 0 mol/L gadobutrol as contrast agent. The dosage of contrast agent was set at 0. 1 mmol/kg body mass. The interval between the two scans was 24-72 hours. The detection and delineation of lesions were evaluated visually. The signal-to-noise ratios (SNR), contrast-to-noise ratios (CNR) of lesion to normal brain white matter and the percentage of lesion enhancement were calculated and compared between the two scans by 2 experienced neuro-radiologists. Results One patient was excluded because he received radiation therapy between the two scans. 15 patients were found to have brain metastases with a total of 35 lesions. There were no statistical differences between the two scans in SNR, CNR and percentage enhancement for both normal brain and lesions (t=0. 545,P=0. 592;t = 1.143,P=2.267,t = 0.592,P = 0. 557;t=0.473,P = 0. 639). Conclusion Half-dose gadobutrol (1.0 mol/L) can achieve the same enhancement effects compared with full-dose multihance (0. 5 mol/L).关键词
钆布醇/钆贝葡胺/脑转移/磁共振成像Key words
Gadobutrol/Multihance/Brain metastasis/MRI引用本文复制引用
李真林,陈宪,夏春潮,孙家瑜,李昌宪,唐鹤菡,宋彬..钆布醇和钆贝葡胺在磁共振成像诊断肺癌脑转移中的对照研究[J].四川大学学报（医学版）,2012,43(4):601-604,4.
