解放军医学杂志2012，Vol.37Issue(6)：638-642,5.
34例肺癌相关性高钙血症患者的生存预后分析
Lung cancer associated hypercalcemia: An analysis of factors influencing survival and prognosis in 34 cases
摘要
Abstract
Objectives To explore the factors influencing survival time in lung cancer associated hypercalcemia patients. Methods Thirty-four patients with pathologically confirmed lung cancer complicated with hypercalcemia, who were treated at the Department of Oncology in General Hospital of PLA from Jan. 2001 to Dec. 2010, were enrolled in this study. The clinical data analyzed included sex, age, pathological type of the malignancies, organ metastasis (bone, lung, liver, kidney, brain), number of distal metastatic site, mental status, interval between final diagnosis of lung cancer and of hypercalcemia, peak value of blood calcium during the disease course, treatment methods and so on. Survival analysis was performed with the Kaplan-Meier method and Cox analysis with statistic software SPSS 18.0 to identify the potential prognostic factors. Results The highest blood calcium level ranged from 2.77 to 4.87mmol/L, and the median value was 2.94mmol/L. The patients' survival time after diagnosis of hypercalcemia varied from 1 day to 1067 days, and the median survival time was 92 days. With the log-rank test, age above SO years old, hypercalcemia occurring over 90 days after diagnosis of cancer, central nervous system symptoms and renal metastasis were predictors for poor survival (P=0.048, P=0.001, P=0.000, P=0.003). In the COX proportional hazard model analysis, age above 50 years old, hypercalcemia occurring over 90 days after cancer diagnosis, central nervous system symptoms and renal metastasis were significant prognostic factors for poor survival (HR=11.483, P=0.006; HR=4.371, P=0.002; HK=6.064, P=0.026; HK=8.502, P=0.01l). Conclusions Patients with lung cancer associated hypercalcemia have a shorter survival time and poor prognosis. Age above SO years old, hypercalcemia occurring over 90 days after cancer diagnosis, central nervous system symptoms and renal metastasis are significant factors of poor prognosis.关键词
高钙血症/肺肿瘤/预后Key words
hypercalcemia/ lung plasmas/ prognosis分类
医药卫生引用本文复制引用
张素洁,王海娟,焦顺昌,刘哲峰,陶海涛,胡毅,钱海利..34例肺癌相关性高钙血症患者的生存预后分析[J].解放军医学杂志,2012,37(6):638-642,5.基金项目
国家自然科学基金(81071773、81101518) （81071773、81101518）
国家973项目(2009CB521807) （2009CB521807）
