解放军医学杂志2012，Vol.37Issue(7)：720-724,5.
育龄期妇女月经紊乱与卵巢储备功能下降的关系
Relationship between menstrual disorders and ovarian reserve function in women at reproductive period
摘要
Abstract
Objective To investigate the relationship between menstrual disorders and ovarian reserve (unction in women at reproductive stage. Methods The clinical data of 282 reproductive-age women treated in our hospital from November 2009 to August 2011 were analyzed retrospectively. Out of them, the control group consisted of 101 women with normal menstruation, while the research group included 181 women with menstrual disorders in the past year, who were again divided into three subgroups according to the duration of menstrual disorders: the patients in group A (n=47) had menstrual disorder for 1-4 months, group B (n=59) for 5-8 months, group C (n=75) for 9-12 months. According to the type of menstrual disorder, the 181 patients were subdivided into 4 groups: group 1 patients (n=62) with reduced menstrual flow, group 2 (n=27) with increased menstrual flow, group 3 (n=35) with shortened menstrual cycles, group 4 (n=57) with prolonged menstrual cycle. The age, serum follicle stimulating hormone (FSH), serum luteinizing hormone (LH), serum estradiol (E2), FSH/LH ratio and number of antral follicles (AFC) were compared between the control group and research one, and between groups A, B and C, and between control group and groups 1, 2, 3 and 4 respectively. Results Compared with the control group, the age, basal FSH level and FSH/LH ratio were significantly higher (P<0.05), while the number of AFC was significantly smaller (P<0.05) in the research group. The differences in the age, FSH level, LH level, FSH/LH ratio and number of AFC were statistically significant between the groups A, B and C (p<0.05), and with the extension of the duration of menstrual disorders, the age, FSH level and FSH/LH ratio were increased, while the LH level and number of AFC decreased. The differences in the FSH level between group 1, group 2 and group 4, respectively, and the control group were statistically significant (P<0.05), and the FSH/LH ratio was significantly increased in all the four subgroups (P<0.05), while the numbers of AFC were all significantly decreased (P<0.05), especially in the group 3. Conclusion Ovarian reserve function of the reproductive-age women with menstrual disorders may hare declined. The duration of menstrual disorders and change in menstrual cycles can be used as sensitive signals for decline of ovarian reserve function in women during reproductive period.关键词
月经紊乱/卵巢储备功能/育龄期妇女/FSH/LH比值Key words
menstrual disorders/ decreased ovarian reserve/ women with procreating period/ the FSH/LH ratio分类
医药卫生引用本文复制引用
何淑明,严东琴..育龄期妇女月经紊乱与卵巢储备功能下降的关系[J].解放军医学杂志,2012,37(7):720-724,5.基金项目
中山市科技局立项资助课题(20102A044) （20102A044）
