解放军医学杂志2012，Vol.37Issue(8)：788-792,5.
自体骨髓干细胞联合脐血单个核细胞移植治疗胸段慢性脊损伤27例报告
Combination of autologous bone marrow mesenchymal stem cells and cord blood mononuclear cells in the treatment of chronic thoracic spinal cord injury in 27 cases
王连仲 1尹忠民 1闻华 1王永才 1张军 2张隽 3陈哲 1胡祥1
作者信息
- 1. 110042 沈阳 解放军463医院神经外科
- 2. 518057 深圳 深圳市北科细胞工程研究所
- 3. 510632 广州 暨南大学医学院
- 折叠
摘要
Abstract
Objective To investigate and evaluate therapeutic effects of transplantation of autologous bone marrow mesenchymal stein cells in conjunction with cord blood mononuclear cells for late thoracic spinal cord injury. Methods Data from 27 patients with late thoracic spinal cord injury who received transplantation of autologous bone marrow mesenchymal stem cells in conjunction with cord blood mononuclear cells in Neurosurgery Department of 463rd Hospital of PLA between July 2006 and July 2008 were collected and analyzed. The full treatment course consisted of 4 consecutive injections at one week apart. Indicators for evaluation followed that of the American Spiral Injury Association (ASIA) Impairment Scale (AIS) grade, ASIA motor and sensory scores, ASIA visual analog score, and the Ashworth score. The follow-up period was 6 months. Evaluations were made 6 weeks and 6 months after the treatment. Results Improvement from AIS A to AIS B was found in 4 patients. In one patient, improvement from AIS A to AIS C and in one patient from AIS B to AIS C was found 6 weeks after the treatment. The AIS improvement rate was 22.2%. In one patient improvement from AIS A to AIS B was found after 6 months. The overall AIS improvement rate was 25-9%. ASIA baseline motor scores of lower extremties were 0.5 ± 1.5, 1.7 ± 2.9, 3.1 ± 3.6 before the treatment, 6 weeks and 6 months after the treatment, respectively, and showed a statistically significant improvement (P<0.05). ASIA sensory scores including light touch and pinprick were 66.6 ± 13.7 and 67-0 ± 13-6 respectively before treatment, and they became 68.8 ± 14-4, 68,4 ± 14.7 and 70,5 ± 14.4, 70.2 ± 14.4 six weeks and six months after the treatment. The changes were statistically significant (P<0.05); Modified Ashworth Scale scores were 1.8 ± 1.5, L6 ± 1.2,1.1 ± 0.8 respectively at baseline, 6 weeks and 6months after the treatment, and showed a statistically significant descending trend (P<0.05). Conclusion Transplantation of autologous bone marrow mesenshymal stem cells in combination with umbilical cord blood mononuclear cells could improve AIS grade, AISA motor and sensory scores to some extent in patients with chronic thoracic spinal cord injury by promoting the recovery of late spinal cord injury.
关键词
干细胞移植/骨髓干细胞/脊髓损伤Key words
stem cell transplantation/ bone marrow cells/ spinal cord injuries分类
医药卫生引用本文复制引用
王连仲,尹忠民,闻华,王永才,张军,张隽,陈哲,胡祥..自体骨髓干细胞联合脐血单个核细胞移植治疗胸段慢性脊损伤27例报告[J].解放军医学杂志,2012,37(8):788-792,5.
