实用临床医药杂志2012，Vol.16Issue(7)：18-20,3.
垂体肿瘤转化基因及碱性成纤维细胞生长因子在乳腺癌组织中的表达及意义
Expressions and significance of pituitary tumor - transforming gene and basic fibroblast growth factor in breast carcinoma
卜迟文 1杨全德 1刘景宏 1陈茜1
作者信息
- 1. 江苏省灌云县人民医院,江苏连云港,222200
- 折叠
摘要
Abstract
To explore the expressions and significance of pituitary tumor -transforming gene (PTTG) and basic fibroblast growth factor (bFGF) in breast carcinoma. Methods A total of 72 samples of breast carcinoma and 20 samples of normal mammary gland adjacent to the breast carcinoma were collected. Immunohistochemistry was employed to detect the expressions of PTTG and bFGF in all the samples. Follow - up was conducted to observe cancer cell metastasis and 5 - year survival rate of the patients. Results PTTG and bFGF expressed negatively in normal mammary gland but positively in breast carcinoma. The probability of metastasis and the death rate in high - expressions were obviously higher than in the low - expressions, and correlation existed between PTTG and bFGF. Conclusion PTTG and bFGF play a role in the formation and the development of breast carcinoma and their expressions relate to the severity and the prognosis of breast carcinoma. Semi - quantitative analysis of PTTG and bFGF in the samples can offer significant reference to the treatment and prognosis of breast carcinoma patients.关键词
垂体肿瘤转化基因/碱性成纤维细胞生长因子/乳腺癌Key words
pituitary tumor- transforming gene/ basic fibroblast growth factor/ breast carcinoma分类
医药卫生引用本文复制引用
卜迟文,杨全德,刘景宏,陈茜..垂体肿瘤转化基因及碱性成纤维细胞生长因子在乳腺癌组织中的表达及意义[J].实用临床医药杂志,2012,16(7):18-20,3.
