实用临床医药杂志2012，Vol.16Issue(9)：1-3,3.
山奈酚对2型糖尿病大鼠糖脂代谢及胰岛素抵抗的影响
Effects of kaempferol on glycolipid metabolism and insulin resistance in rats with type 2 diabetes
摘要
Abstract
Objective To explore the effects of peroxisome proliferator - activated receptor gamma (PPAR-γ) agonists on blood glucose, insulin resistance and blood lipids in rats with type 2 diabetes. Methods Rat model was established by consuming high - sugar and high - fat diet and intrap-eritoneal injection of streptozotocin. The treatment groups were administered 50 mg/( kg?d), 100 mg/(kg·d), and 200 mg/(kg·d) of kaempferol for 10 weeks respectively. Pasting blood glucose and plasma insulin levels were detected by glucose oxidase method and radioimmunoassay, respectively. Plasma concentrations of total cholesterol, triglycerides, blood urinary nitrogen and creatinine were determined by enzymology. Results The fasting blood glucose, plasma insulin resistance and blood lipids were noticeably decreased in the treatment groups. Compared with the model group, the differences were statistically significant. Conclusion Kaempferol can effectively decrease fasting blood glucose and insulin resistance and improve the disorders of glucose and lipid metabolism.关键词
山奈酚/2型糖尿病/胰岛素抵抗/糖脂代谢/大鼠Key words
kaempferol/type 2 diabetes/insulin resistance/glycolipid metabolism/rats分类
生物科学引用本文复制引用
刘贵波,刘跃光,孙成,包海花,于建渤..山奈酚对2型糖尿病大鼠糖脂代谢及胰岛素抵抗的影响[J].实用临床医药杂志,2012,16(9):1-3,3.基金项目
黑龙江省教育厅科学技术研究资助项目(11531400) （11531400）
