实用临床医药杂志2012，Vol.16Issue(9)：15-17,3.
2型糖尿病患者胰岛素泵强化治疗后皮下注射胰岛素3种方式的疗效比较
Efficacy comparison of three modes of insulin injection after intensive therapy using a insulin pump in patients with type 2 diabetes
摘要
Abstract
Objective To observe and compare the rate of blood glucose up to standard, levels of blood glucose control and incidence rate of hypoglycemia between daily multiple insulin injection and mixed insulin therapy in patients with type 2 diabetes (T2D) after short - term intensive therapy of continuous subcutaneous insulin infusion(CSII). Methods T2D patients received short -term intensive therapy of CSII to control blood glucose level. When the blood glucose level acquired good control after about 7-10 days, the patients were randomly divided into group A (pre-mixed human insulin 70/30, subcutaneous injection, twice daily pre-breakfast and pre-dinner), group B (r - human insulin and NPH insulin, subcutaneous injection, q. i. d.) and group C (glargine and aspart, subcutaneous injection, q. i. d. ). The conditions of blood glucose level inciud-ing the rate of blood glucose up to standard, diurnal glucose fluctuation and incidence rate of hypoglycemia were compared between the 3 groups. Results There was no statistically significant difference in the rate of blood glucose up to standard between groups B and C, which was higher in groups B and C than in group A. The incidence rate of hypoglycemia was lower in group C than in group A (F<0.05), but the difference both between groups A and B and between groups B and C were statistically insignificant. The differences in the diurnal blood glucose fluctuations between the three groups were statistically insignificant. Conclusion All the three modes of treatment can make blood glucose reach standard level and obtain similar blood glucose control. Compared with group A, groups B and C has higher rates of blood glucose up to standard, lower incidence rate of hypoglycemia, better efficacy and safety.关键词
2型糖尿病/胰岛素泵/多次皮下注射Key words
type 2 diabetes/continuous subcutaneous insulin infusion/insulin pump/multiple subcutaneous injection分类
医药卫生引用本文复制引用
王晓薇..2型糖尿病患者胰岛素泵强化治疗后皮下注射胰岛素3种方式的疗效比较[J].实用临床医药杂志,2012,16(9):15-17,3.基金项目
中国高校医学期刊临床专项资金(11220048) （11220048）
