实用临床医药杂志2012，Vol.16Issue(11)：13-16,4.
血清CA153、CEA水平与乳腺癌骨转移的相关性研究
Correlational study on the levels of serum CA153 and CEA and bone metastases of breast cancer
摘要
Abstract
Objective To explore the predictive value of serum tumor levels of carbohrdyate antigen (CA) 153 and carcinoembryonic antigen (CEA) for bone metastases of breast cancer patients. Methods The serum levels of CA153 and CEA in 39 patients were determined before and after diagnosis of bone metastases by enzyme linked immunosorbent assay (ELISA). Results Serum levels of CA153 and CEA before and after metastases showed significant differences, which also showed significant correlation with bone metastases. Serum levels of CA153 in patients with human epidermal growth factor receptor 2 (HER - 2) ( - ), before menopause, stage Ⅲ - IV and bone metastatic regions>5 showed significant differences afier metastases (p<0.05). Serum levels of CA153 in patients with HER- 2( - ) .stage HI - IV, bone metastatic region>5, ectosteal bone metastatic region< 1, progesstrogen receptor (PR)( - ) showed significant correlation with bone metastases (p<0.05). Serum levels of CEA in patients with HER - 2 ( - ), after menopause, stage II , bone metastatic region≤5, bone metastatic region>5, epidermal receptor (ER)( - ), ER( + ), PR(-), PR( + ) were significantly increased, and showed significant correlation with bone metastases ( P < 0.05). Conclusion The increase of tumor serum levels of CA153 and CEA is correlated with the bone metastases of breast cancer and it is thus of predictive value.关键词
乳腺癌/骨转移/CA153/CEAKey words
breast cancer/ bone metastasis/ carbohrdyate antigen(CA) 153/ carcinoembryonic antigen (CEA)分类
医药卫生引用本文复制引用
黎秀月,张军一,陈晓华,陈旭坚,曹小龙,陈逢生,罗荣城..血清CA153、CEA水平与乳腺癌骨转移的相关性研究[J].实用临床医药杂志,2012,16(11):13-16,4.基金项目
国家自然科学基金资助项目(30801308) （30801308）
广东省广州市番禺区科技计划资助项目(2011Z0320) （2011Z0320）
