摘要
Abstract
Objective To observe the efficacy and safety of different doses of rosuvastatin in carotid atherosclerosis patients complicated with hyperlipidemia, and conduct a comparative analysis. Methods A total of 110 carotid atherosclerosis patients complicated with hyperlipidemia from May 2008 to May 2011 were selected and randomly divided into rosuvastatin 5mg group (group A), 10 mg group (group B), and 20 mg group (group C). The medicine was administered after dinner. The changes of TC, TG, HDL-C, LDL-C, carotid plaque area, neck intima - media thickness (IMT) in the three groups were compared and the incidence of adverse events were recorded. Results The carotid plaque area and carotid intima - media thickness were significantly reduced (P <0.01), TC, TG, LDL-Cwere significantly lowered (P<0.01) and HDL - C were significantly increased (P<0.01) in all three groups. But the overall efficacy rate in group C was better than in group B, and group B better than group A(P<0.05orP<0.01). No obvious adverse events were found in all the three groups before and after the treatment. Conclusion Rosuvastatin is effective in treating carotid atherosclerosis patients complicated with hyperlipidemia. It can significantly lower lipid, and have and - inflammatory and anti - atherosclerosis effect. But it is dose - dependent. No serious adverse events of the three doses were found in the study. Therefore safety is commendable.关键词
瑞舒伐他汀/颈动脉粥样硬化/高血脂/颈动脉斑块面积/颈内膜-中膜厚度Key words
rosuvastatin/ carotid atherosclerosis/ hyperlipidemia/ carotid plaque area/ intima media thickness (IMT)分类
医药卫生
