临床口腔医学杂志2012，Vol.28Issue(7)：402-405,4.DOI:10.3969/j.issn.1003-1634.2012.07.006
不同雌激素对慢性间歇性低氧去卵巢大鼠颏舌肌功能的影响比较
Effects of different estrogen on genioglossus function of ovariectomized rats with chronic intermittent hypoxia
摘要
Abstract
Objective: To investigate the effects of different estrogen on genioglossus (GG) function of ovariectomized rals with chronic intermittent hypoxia. Method: Forty female SD rats (8 weeks old) were randomly divided into five groups after ovariectonry:norrmoxia control group (NC) , chronic intermittent hypoxia group (C1H) , estradiol group (E2) ,genistein group (GEN), resveratrol group (RES). Rats in the latter four groups were used to build CIH models. In the latter three groups, eslradiol, genistein and resveratrol were administered respectively by intraperitoneal injection daily in the last 4 days of CIH exposure, and the dose was 2.5 mg/ kg/ day. Rals in the NC and CIH groups were intraperitoneally injected with DMSO as a control. After CIH exposure, the rats were anesthetized,and the GG were isolated. The contractile characteristics of the whole GG were measured in response to stimulation of the hypogloeaal medial nerve branch. Result: 5 -No significant difference was observed in twitch tension and initial tetanic tension between the five groups (P >0.05). 2. A significant increase in GG fatigue resistance was observed in E2 group, GEN group and RES group compared with CIH group (P <0.01). Only a slight decrease was examined in E2 group as compared with NC group (P >0.05). The fatigue resistance of GEN group and RES group were observed to be significantly lower than that of NC group and E2 group (P<0.01). Besides,there was an insignificant increase in RES group in contrast to GEN group (P >0.05). Conclusion: Though being no match for eslradiol, phyloesuogen could increase the fatigue resistance of GG in CIH ovariectomized rats to some extent.whose mechanism still need more research.关键词
颏舌肌/雌激素/慢性间歇性低氧/收缩功能Key words
genioglossus/ estrogen/ chronic intermittent hypoxia/ contractile property分类
医药卫生引用本文复制引用
卢芸,刘月华..不同雌激素对慢性间歇性低氧去卵巢大鼠颏舌肌功能的影响比较[J].临床口腔医学杂志,2012,28(7):402-405,4.基金项目
国家自然科学基金项目(30973362) （30973362）
