临床口腔医学杂志2012，Vol.28Issue(8)：464-466,3.DOI:10.3969/j.issn.1003-1634.2012.08.006
针刺对舌癌变模型大鼠血清CD4+和CD8+的影响研究
Effects on blood serum CD4+ and CD8+ intervened by acupuncture on tongue cancer rats model
摘要
Abstract
Objective: To explore the effects of immune function of tongue cancer rats model intervened by acupuncture. Method: Using 0.002 % 4-Nitroquinoline 1-oxide (4NQO) in drinking water to establish the rats model for oral mu-cosa carcinogenesis,acupuncture was implemented in 13-18 weeks,positive controlled by retinoic acid,to observe the alteration of oral mucosa morphology by HE stain and the quantity of blood serum CD4+ and CD8+ by Enzyme linked immunosor-bent assays (ELISA). Result: Histopathology makes it clear that atypical hyperplasia and Cancerous degree of model group is the most serious one,medicine group takes second place,and the destructiveness of acupuncture group is the lowest. Contrast to black control group,Serum CD4+ in other groups increase,in which the acupuncture group is remarkable,making a significant difference (P <0.05) ; both serum CD8+ and CD4+/ CD8+ ratio of acupuncture group increases (P <0.05) ,and decres respectively more than model group and medicine group,closing to black group. Conclusion: To a certain extent,it is obviously illustrated (P <0.05) and decrease respectively that there is inhibition effect of acupuncture in the occurrence and development of oral mucosa carcinogenesis,relevance to rats immune function regulation probably.关键词
针刺/口腔黏膜癌变/免疫功能/CD4+/CD8+Key words
Acupuncture/Oral mucosa cancer/CD4+/CD8+引用本文复制引用
经典,贾燕飞,周红梅,刘传霞,张琳,周奇志..针刺对舌癌变模型大鼠血清CD4+和CD8+的影响研究[J].临床口腔医学杂志,2012,28(8):464-466,3.基金项目
国家自然科学基金资助项目(81173322,81172581) （81173322,81172581）
四川省科技厅应用基础研究项目(2010JY0036) （2010JY0036）
