临床与实验病理学杂志2012，Vol.28Issue(9)：963-966,4.
乳腺癌中S100A7与AKT的表达及意义
Detection of S100A7 and AKT expression in breast cancer
摘要
Abstract
Purpose To understand the different expression of S100A7 and AKT in breast cancer and their correlations. Methods Immunohistochemical PV non-biotin two-step method was used to examine expression of S100A7 and AKT in 226 cases of breast cancer, and their correlations with clinicopathological features involving ER, PR, and Her-2 status in breast cancer. Results The expression of S100A7 protein in ductal carcinoma in situ, was high ( 52. 50% ), while the positive expression rate of AKT in breast invasive ductal carcinoma increased ( 50. 00% ), the expression of both S100A7 and AKT was higher in cases with lymph node metastasis( P = 0. 006 2, P = 0. 044 8 ), and the expression rate in stage Ⅲ was higher than that in stages I and Ⅱ ( P = 0. 025 8, P = 0. 040 3 ). The correlation of AKT expression with tumor size was significant ( P =0. 031 0 ). The expression of SI00A7 and AKT in breast cancer had negative correlation with ER and PR status, and positive correlation with Her-2 amplification. Conclusion Detection of SI00A7 and AKT proteins in breast cancer cells plays an important role in the pathologic study, which likely provide new targets for breast cancer treatment.关键词
乳腺肿瘤/S100A7/AKTKey words
breast neoplasms/ SI00A7/ AKT分类
医药卫生引用本文复制引用
孙丽梅,王健,田连胜,马红艳,王鲁建,魏敏杰,米小轶..乳腺癌中S100A7与AKT的表达及意义[J].临床与实验病理学杂志,2012,28(9):963-966,4.基金项目
辽宁省教育厅高等学校科研项目(L2010570) （L2010570）
