南京农业大学学报2012，Vol.35Issue(4)：110-114,5.
恩诺沙星在异育银鲫体内的组织分布及消除规律
Distribution and elimination of enrofloxacin in allogynogenetic silver crucian carp, Carassius auratus gibelio
摘要
Abstract
The distribution of enrofloxacin ( EF) in tissues was investigated after single intravenous (i. v. ) and oral ( p. o. ) administration of 10 mg·kg‐1 body weight in allogynogenetic silver crucian carp at 24-26 ℃. The tissue concentration of EF was determined by high-performance liquid chromatography( HPLC). A two-compartment model kinetics was observed following i. v. administration. The plasma concentration-time data following p. o. administration showed a double peak-shaped curve, indicating the possibility of enterohepatic recirculation of EF in allogynogenetic silver crucian carp. The absorption of EF was very good with a bio-availability( F) of 86%. After both administrations, the distribution of drug was extensive, the AUC in kidney, muscle, Hepatopancreas,gill and blood was 624.2,965.9,721.8,298.0,239.6 μg·h·mL‐1 and 465-3,343.1,542.9,411.4,205.9 μg·h·mL‐1, respectively;the Cmax in five tissues was 33.48,16.91,26.44,18.71 μg·g‐1 and 15.30 μg·mL‐1 ,9.20,5.39,7.78,6.88 u.g·g‐' and 4.50 μg·mL‐l,respectively. The depletion time of EF was considerably long,the Tl/2β of drug in five tissues was 169.0,141.4, 113.4,36.7,63.5 h and 27. 3,49. 2,77.0,38.5,62. 7 h,respectively. Conclusion: EF administered p. o. at a dose of 10 mg·kg‐1 might offer a good option for the treatment of infectious diseases in allogynogenetic silver crucian carp,while its relatively long T1/2β indicated a long withdrawal period.关键词
恩诺沙星/异育银鲫/组织分布/消除规律Key words
enrofloxacin/allogynogenetic silver crucian carp/tissue distribution/elimination regularity分类
农业科技引用本文复制引用
方星星,刘秀红,丁相卿,赵文婷,刘文斌,陆承平..恩诺沙星在异育银鲫体内的组织分布及消除规律[J].南京农业大学学报,2012,35(4):110-114,5.基金项目
农业部水生动物遗传育种和养殖生物学重点开放实验室开放基金(BZ2007-04) （BZ2007-04）
