南京医科大学学报（自然科学版）2012，Vol.32Issue(6)：784-789,6.
PTPRO在肝细胞肝癌中表达的性别差异及其与预后的关系
Study of PTPRO level in human hepatocellular carcinoma and its correlation with gender and prognosis
摘要
Abstract
Objective:To investigate the expression and gender disparity of protein tyrosine phosphatase reeeptor-type 0 (PTPRO) in human hepatocellular carcinoma (HCC), the correlation of PTPRO with carcinoma recurrence after hepatectomy,and whether PTPRO can be served as a desirable prognostic index. Methods: PTPRO expression of HCC tissue and adjacent tissue in 59 male and 22 female patients were determined by real-time PCR and immunohistochemistry(IHC),as well as estrogen receptors(ERs). Gender disparity of PTPRO and ERs and the correlation between PTPRO and ERs were analyzed by ( test,correlation analysis and F lest;The correlation between PTPRO level and post-hepaleclomy recurrence rate of HCC patients were analyzed by Kaplan-Meier curve and log-rank test. Results:Expression of PTPRO and ERa in HCC tissues were significantly lower than adjacent cirrhotic tissues (P < 0.000 1);Expressions of PTPRO and ERa of adjacent tissue was lower in male than in female (P < 0.05);Expression of PTPRO was negatively correlated to recurrence of HCC patients (P < 0.000 1). Conclusion::PTPRO is a potential tumor suppressor with gender disparity,and can serve as a candidate for predicting recurrence after surgical resection of HCC.关键词
PTPRO/雌激素受体/肝细胞肝癌/复发率Key words
PTPRO/estrosen receptor/hepatocellular carcinoma/recurrence分类
医药卫生引用本文复制引用
侯嘉杰,姜润秋,邓蕾,陈晨,孙倍成..PTPRO在肝细胞肝癌中表达的性别差异及其与预后的关系[J].南京医科大学学报（自然科学版）,2012,32(6):784-789,6.基金项目
卫生部科研基金(LW201001) （LW201001）
国家自然科学基金(81072029和91029721) （81072029和91029721）
教育部大学新世纪杰出人才计划(NCET-09-0160) （NCET-09-0160）
南京医科大学第一附属医院创新团队发展计划和江苏省高等教育委员会优先学术计划的部分支持 （）
