南京医科大学学报（自然科学版）2012，Vol.32Issue(6)：819-822,4.
Mcl-1在宫颈癌组织中的表达及临床意义
The expression and clinical significances of Mcl-1 in cervical cancer
摘要
Abstract
Objective;To investigate the expression profile of Mcl-1 in cervical cancer and its relationship with the clinical pathological characteristic,and to assess its clinical significance. Methods;Mel-lmRNA expression both in cervical cancer and in corresponding normal tissue was detected by reverse transcription fluorescent quantitation polymerase chain reaction method. Mel-1 protein expression was detected by immunohistochemistry method. The correlation of Mcl-1 expression and clinicopathological features of cervical cancer was analyzed. Results; Mcl-lmRNA was higher in cervical cancer tissue when compared with corresponding normal tissue. Mcl-1 was overexpressed in cervical cancer tissue (positive rate of 53.3%) when compared with corresponding normal tissue (positive rate of 11.1%). High expression of Mcl-1 was significantly correlated with histological grade,tumor size and lymph node involvement (P< 0.05). Conclusion:Our results suggest that Mcl-1 may play an important role in cervical cancer and have potential as biomarker and therapeutic target.关键词
宫颈癌/Mcl-1/肿瘤生物学特性Key words
cervical cancer/Mcl-l /oncobiology characteristic分类
医药卫生引用本文复制引用
张婷,赵纯,项静英..Mcl-1在宫颈癌组织中的表达及临床意义[J].南京医科大学学报（自然科学版）,2012,32(6):819-822,4.基金项目
无锡市科技局科研项目(CSE00949) （CSE00949）
南京医科大学科技发展基金面上项目(08NMUM080) （08NMUM080）
