南京医科大学学报（自然科学版）2012，Vol.32Issue(6)：845-848,4.
奥拉西坦对不同程度血管性认知障碍的疗效比较
Clinical effects of oxiracetam for treatment of vascular cognitive impairment in varying degree
摘要
Abstract
Objective:To investigate the effects of oxiracetam treatment for vascular cognitive impairment(VCI) in varying degrees. Methods;Sixty patients with VCI were selected. Among them,30 patients were with vascular cognitive impairment no dementia (VCIND)and 30 patients with vascular dementia (VD). All patients received conventional base treatment and the oxiracetam treatment. The event-related potentials P300(ERP-P300) and Montreal cognitive assessment(MoCA) of all patients were observed and compared before and after the treatment. Results: After the treatment, the scores of MoCA of all patients showed improvement (VCIND:t = 11.886,P < 0.01:VD;l = 2.242,P < 0.05). After the treatment,ERP-P300 of the VCIND group was improved significantly,the latency period of ERP-P300(P300-PL) was significantly shortened(t = 5.799,P< 0.01) while the amplitude (P300-Amp) was significantly increased (t = 17.603,P < 0.01 );but the ERP-P300 of the VD group had no obvious improvement (PL:t = 1.414,P > 0.05;Amp:t = 1.069,P > 0.05). There were significant differences in the scores of MoCA,the latency period and amplitude of ERP-P300 between VCIND group and VaD group (t = 2.135,4.402,7.682,P < 0.05). Conclusion: Oxiracetam are beneficial in the treatment of VCI,especially effective to the patients with VCIND.关键词
认知障碍/血管性/奥拉西坦/治疗效果Key words
cognitive impairment/vaseular/oxiraeetam/treatment outcome分类
医药卫生引用本文复制引用
韩颖,刘青蕊,李来有,史欣,王娇兰..奥拉西坦对不同程度血管性认知障碍的疗效比较[J].南京医科大学学报（自然科学版）,2012,32(6):845-848,4.基金项目
河北省卫生厅医学科学研究重点课题(20100422) （20100422）
