南京医科大学学报（自然科学版）2012，Vol.32Issue(6)：871-874,4.
Stat3及Bcl-2在口腔黏膜癌前病变癌变中mRNA表达的相关性研究
The mRNA expression of Stat3 and Bcl-2 in process of malignant change of oral mucosa
摘要
Abstract
Objective;To research the mRNA expressions of Stat3 and Bcl-2 in process of malignant change of oral premalignant lesions. Methods;The mRNA expressions of Stat3 and Bcl-2 were detected in normal oral mucosa,simple hyperplasia epithelia,dys-plasia epithelia and oral squamous cell carcinoma (OSCC) by RT-PCR. Results;The positive rate of Stat3 and Bcl-2 and the semi-quantitative value (Slat3/GAPDH,Bcl-2/GAPDH) increased stepwise from normal mucosa,hyperplasia epithelia,dysplasia epithelia to OSCC. The expression of Stat3 was linear positively correlated to that of Bcl-2. Conclusion;There is some relation among Stat3, Bcl-2 and the process of malignant change of oral premalignant lesions.关键词
Stat3/Bcl-2/RT-PCR/癌前病变/口腔黏膜Key words
Stat3/ Bcl-2/ RT-PCR/ premalignant lesions/ oral mucosa分类
医药卫生引用本文复制引用
钱棱,吴国英,袁俊,胡明,李留炀,杨静..Stat3及Bcl-2在口腔黏膜癌前病变癌变中mRNA表达的相关性研究[J].南京医科大学学报（自然科学版）,2012,32(6):871-874,4.基金项目
江苏省教育厅自然科学研究基金(03KJD32-0148) （03KJD32-0148）
