南京医科大学学报（自然科学版）2012，Vol.32Issue(7)：976-982,7.
MCT1、CD147、CD44在非小细胞肺癌中表达的相关性及意义
Relevance and significance of expressions of MCT1 ,CD147 and CD44 in non-small cell lung cancer
摘要
Abstract
Objective:To investigate the protein and mRNA expression of monocarboxylate transporters I (MCT1),CD147 and CD44 in non-small cell lung cancer(NSCLC) ,and significance of their clinical pathology. Methods: Fifty-six specimens of the NSCLC and peritumoral tissues and twenty-one control specimens of pulmonary benign diseases were studied. The mRNA and protein expressions of MCT1,CD147 and CD44 in specimens were analyzed by real-time quantitative reverse transcriptase polymerase chain reaction (real-time quantitative RT-PCR) and immunohistoehemistry. Results: ①The positive expression rates of MCT1,CD147 and CD44 were significantly higher in NSCLC tissues than those in the peritumoral and control tissues (P < 0.05); ② The MCT1 expression in the cell membrane was correlated with both CD147 and CD44 expressions (P < 0.05); ③ The expressions of MCT1, CD147 and CD44 in NSCLC were not correlated with age,gender,lesion dimension and TNM stage,but significantly correlated with histological types of tumor and lymph node metastasis (P < 0.05). And the mRNA and protein expressions of MCT1 and CD44 in NSCLC was correlated significantly with tumor differentiation degree (P < 0.05). Conclusion: MCT1,CD147 and CD44 may participate in the occurrence and development of NSCLC,and may be act as the diagnose and prognosis index of NSCLC.关键词
非小细胞肺癌/单羧酸转蛋白1/CD147/CD44Key words
non-smalt cell lung cancer/ monoearboxylate transporters 1/ CD147/CD44分类
医药卫生引用本文复制引用
王平,朱超男,彭浩,周建宏,杨慧..MCT1、CD147、CD44在非小细胞肺癌中表达的相关性及意义[J].南京医科大学学报（自然科学版）,2012,32(7):976-982,7.基金项目
云南省卫生厅科技内设研究机构项目(2011WS0005) （2011WS0005）
