南京医科大学学报（自然科学版）2012，Vol.32Issue(7)：983-988,6.
TK1、Ki-67在非小细胞肺癌组织中的表达及预后意义
The expression and prognostic significance of TK1 and Ki-67 in non-small cell lung cancer
摘要
Abstract
Objective;To investigate the expressions of thymidine kinase 1(TK1) and Ki-67 in non-small cell lung cancer(NSCLC) and their prognostic value in NSCLC. Methods:The tissue microarrays which contain 202 NSCLC cases and 63 normal lung cases were constructed. The expressions of TK1 and Ki-67 were detected in these tissues by immunohistoehemistry method. The relationship between expression levels of two makers and the clinicopathological and survival parameters of NSCLC were evaluated. Results: The positive expression rates of TK1 (60.89%)and Ki-67 (55.45%)in the NSCLC tissues were significantly higher than those in normal tissue group (P < 0.000 \,P < 0.000 5). The Spearman correlation analysis showed that the expression of TK1 were positively correlated with Ki-67 expression (r = 0.518,P < 0.001). In the group of NSCLC, both TK1 and Ki-67 expression were significant correlated with tumor grade and TNM stage. Kaplan-Meier survival analysis indicated that the survival rate was markedly lower in patients with high expression level of two markers than those with low expression level (P < 0.05),Multivariate analysis using Cox regression model identified that TNM stage and TK1 expression were independent prognostic factors of NSCLC (P < 0.05). Conclusion;The expression of TK1 was significantly correlated with tumor grade and TNM stage. TK1 might be employed to evaluate the prognosis of NSCLC patients.关键词
细胞质胸苷激酶1/Ki-67/非小细胞肺癌/组织芯片/预后Key words
thymidine kinase 1/Ki-67/non-small cell lung cancer/tissue microarray/prognosis分类
医药卫生引用本文复制引用
冯蕾,饶秋,刘标,樊祥山,石永利,孟凡青,冯振卿..TK1、Ki-67在非小细胞肺癌组织中的表达及预后意义[J].南京医科大学学报（自然科学版）,2012,32(7):983-988,6.基金项目
江苏省卫生厅科研基金(H200938) （H200938）
