南京医科大学学报（自然科学版）2012，Vol.32Issue(7)：989-994,6.
多原发膀胱癌与单发膀胱癌中P53、Bcl-2、C-erbB-2、EGFR的表达及临床意义
Expressions and significances of P53,Bcl-2,C-erbB-2 and EGFR in patients with multiple primary bladder cancers and single bladder cancers
摘要
Abstract
Objective:To study the expression and clinical features of P53,Bcl-2,C-erbB-2 and (epidermal growth factor receptor, EGFR) in multiple primary bladder cancers and single bladder cancers,and provide evidence for diagnosis and targeted treatment of multiple primary bladder cancer. MethodS:Immunohistochemical SP methods were used to detect the expression of P53,Bcl-2,C-erbB-2 and EGFR in 15 patients with multiple primary bladder cancers, 15 patients with single bladder cancers (The clinical stage and pathological grade of patients with single bladder cancers were similar to those with multiple primary bladder cancers.) and 15 patients with normal bladder, the differences of the expression of P53, Bcl-2, C-erbB-2 and EGFR in each group were analyzed. Results;The positive expressions of P53,Bcl-2,C-erbB-2 and EGFR in patients with multiple primary bladder cancers and single bladder cancers were significantly higher than those in patients with normal bladders (P < 0.05). The positive expressions of P53 and Bcl-2 in multiple primary bladder cancer tissues were higher than those in single bladder cancer tissues(P < 0.05),while the positive expressions of C-erbB-2 and EGFR in multiple primary bladder cancer tissues were significantly lower than those in single bladder cancer tissues (P < 0.001). Conclusion:The positive expressions of P53,Bcl-2,C-erbB-2 and EGFR were different between multiple primary bladder cancers and single bladder cancers (P < 0.05). The combined detection of P53, bcl-2, C-erbB-2 and EGFR is valuable for the clinical diagnosis and identification of multiple primary bladder cancers. This study provides the possibility of the targeting therapy of multiple primary bladder cancers.关键词
多原发膀胱癌/膀胱癌/P53/Bcl-2/C-erbB-2/EGFRKey words
multiple primary bladder cancers/bladder cancer/P53/Bcl-2/C-erbB-2/EGFR分类
医药卫生引用本文复制引用
祝庆亮,王楠,谷江,张永春,石家齐,孙发,龙义国,沈俊,万滨,杨永安..多原发膀胱癌与单发膀胱癌中P53、Bcl-2、C-erbB-2、EGFR的表达及临床意义[J].南京医科大学学报（自然科学版）,2012,32(7):989-994,6.基金项目
贵州省科技厅基金资助[黔科合J字(2010)2176号] （2010）
贵阳市社会发展科技攻关项目基金资助(2010筑科农合同第1-社-24号) （2010筑科农合同第1-社-24号）
