南京医科大学学报（自然科学版）2012，Vol.32Issue(8)：1057-1060,4.
室间隔缺损膜部瘤组织内细胞增殖和生存能力分析
Proliferation and survival analysis of aneurysms of membranous septum associated with perimembranous ventricular septal defect
摘要
Abstract
Objective:To explore the pathological characteristics of aneurysms of membranous septum (AMS) associated with perimembranous ventricular septal defect by analyzing cell proliferation and survival. Methods,The structure of AMS was analyzed by HE staining. Immunohistochemical staining of Ki67 and phosphorylated Akt(pAkt) was performed to identify cell proliferation and survival in AMS. Results: HE staining showed that the number of cells in false AMS was more than that in true AMS,but the extracellular matrices of false AMS were less compact than those of true AMS. Much more Ki67 positive cells in false AMS suggested a more powerful proliferation than true AMS. pAkt staining was only found in endothelial and subendothelial cells in false AMS. Conclusion: False AMS demonstrates stronger ability of cellular proliferation and survival indicating it's an active tissue.关键词
膜周部室间隔缺损/室间隔膜部瘤/增殖/磷酸化 AktKey words
perimembranous ventricular septal defect /aneurysm of membranous septum proliferation/ phosphorylated Akt分类
医药卫生引用本文复制引用
孙伟,李名鹏,缪利平,吴延虎,孔祥清..室间隔缺损膜部瘤组织内细胞增殖和生存能力分析[J].南京医科大学学报（自然科学版）,2012,32(8):1057-1060,4.基金项目
江苏省科技厅社会发展项目(BE2011800) （BE2011800）
