南京医科大学学报（自然科学版）2012，Vol.32Issue(8)：1066-1069,4.
应用组织芯片技术检测结直肠癌中MRP1/CD9的表达
Detecting of MRP1/CD9 in colorectal carcinoma using tissue microarrays
摘要
Abstract
Objective :To investigate the expression of MRP1/CD9 as well as their correlations with the metastasis of colorectal carcinoma. Methods: Tissue microarray and immunohistoehemistry were used to detect the expression of MRP1/CD9 in 244 cases of eolorectal carcinoma. ResultS:The positive rate of MRP1/CD9 expression was 77.9% in colorectal carcinoma. The expression of MRP1/CD9 had no relationship with the patients' sex,age,and the depth of infiltration,but it had relationships with the differentiated degree,Dukes stages,and lyniphnode metastasis. The expression of MRP1/CD9 was higher in colorectal carcinomas with moderate or high differention than that in the ones with poor differention. The expression of MRP1/CD9 was higher in colorectal carcinomas with Dukes A+B stages than that in the ones with Dukes C+D stages. The expression of MRP1/CD9 was higher in colorectal carcinomas without lymphnode metastasis than that in the ones with lyniphnode metastasis. Above all had the significant meaning (P < 0.05). Forward stepwise binary logistic regression reveals,differentiation,which went into the equation first,is the significant factor of MRP1/ CD9 expression. The expression of MRP1/CD9 was negatively related to Dukes stages in monofactoral analysis,but disappearing in multifactoral analysis. Conclusion:The loss expression of MRP1/CD9 are closed correlated with the metastasis of colorectal carcinoma,and this marker has hopes to become a new target to evaluate the tumor prognosis.关键词
结直肠癌/MRP1/CD9/转移/组织芯片/免疫组织化学Key words
colorectal carcinoma/MRPl/CD9/metastasis/tissue microarray/immunohistoehemistry分类
医药卫生引用本文复制引用
季润元,史恩溢,王永实,李小宁,赵玉芳..应用组织芯片技术检测结直肠癌中MRP1/CD9的表达[J].南京医科大学学报（自然科学版）,2012,32(8):1066-1069,4.基金项目
江苏省卫生厅医学科技发展基金(J201116) （J201116）
