南京医科大学学报（自然科学版）2012，Vol.32Issue(8)：1103-1105,3.
2型糖尿病患者血浆纤维蛋白原与牙周病的关系
Correlation between plasma fibrinogen in type 2 diabetic patients and periodontal disease
摘要
Abstract
Objective:To investigate plasma fibrinogen levels in type 2 diabetic patients with periodontal disease,and to explore the correlation between plasma fibrinogen and penodontal diseases in type 2 diabetic patients. Methods : The study included 24 type 2 diabetic patients complicated with severe periodontal diseases,20 type 2 diabetic patients without periodontal diseases and 16 normal controls. The body mass index (BMI) was calculated,and plasma fibrinogen and blood lipids,HbAlc were determined. Results: Compared with normal control and type 2 diabetic subjects without periodontal diseases,plasma fibrinogen levels in type 2 diabetic patients with severe periodontal diseases were significantly increased. Plasma fibrinogen level in type 2 diabetic patients without periodontal diseases was significantly elevated compared with normal controls(P< 0.05). The plasma fibrinogen levels were positively correlated with HOMA-IR,HbAlc. Conclusion:Periodontal diseases may result in higher circulating fibrinogen in type 2 diabetic patients, and aggravate glucose metabolic disorder and insulin resistance.关键词
2型糖尿病/牙周病/纤维蛋白原Key words
type 2 diabetic mellitus/periodontal disease/plasma fibrinogen分类
医药卫生引用本文复制引用
郝涛,高琳..2型糖尿病患者血浆纤维蛋白原与牙周病的关系[J].南京医科大学学报（自然科学版）,2012,32(8):1103-1105,3.基金项目
贵州省卫生厅科技基金项目(D-276) （D-276）
遵义医学院中青年科技基金项目(F-185) （F-185）
