南京医科大学学报（自然科学版）2012，Vol.32Issue(8)：1140-1143,4.
腺苷负荷核素心肌灌注显像对冠心病的诊断价值及其安全性观察
The application and safty of adenosine stress myocardial perfusion tomographic imaging in detecting coronary artery disease
摘要
Abstract
ObjectiveTo analyze the sensitivity and specificity of adenosine stress myocardial perfusion imaging for the diagnosis of coronary artery disease (CAD) and to observe the adverse reaction of adenosine burden teast. Methods, A total of 85 inpatients were included in this study. SPECT myocardial imaging acquisition was obtained 1 hour after adenosine infusion. Rest myocardial perfusion imaging would be performed next day regularly. Coronary angiography was performed in 67 patients within one month of myocardial imaging. Results: (1) Total 85 cases [(66 ± 9) years old,46 men,39 women]were included in this study. In the 52 cases of CAD patients confirmed by coronary angiography,46 patients have positive adenosine 9900Tc-MIBl myocardial perfusion SPECT. Of 15 cases without CAD, 11 cases have negative adenosine myocardial perfusion tomographic imaging. The sensitivity and specificity of adenosine myocardial perfusion tomographic imaging for the diagnosis of CAD were 88.5% and 73.3%. (2) In the 85 patients, 8.3% patients had no symptom,91.7% had varied kinds of adverse reaction,consisted of chest complaint (83.3%),skin aestus (23.1% ),dizziness (20.5%),palpitation (12.8%).short breath (7.7%),sweating (7.7%) and so on. At the end of 5 minutes of stopping adenosine infusion,all adverse reaction disappeared,heart rate and blood pressure returned to basal level- Conclusion:Adenosine stress myocardial perfusion tomographic imaging is an useful and safty non-interventional method for detecting coronary artery disease.关键词
冠心病/核素心肌灌注显像/腺苷/心脏负荷试验/不良反应Key words
coronary disease/myocardial perfusion imaging/adenosine/burden test/adverse reaction分类
医药卫生引用本文复制引用
袁冬兰,袁冬青,冯建林,周艳丽,赵中强,陈建玉,李殿富..腺苷负荷核素心肌灌注显像对冠心病的诊断价值及其安全性观察[J].南京医科大学学报（自然科学版）,2012,32(8):1140-1143,4.基金项目
江苏省兴卫工程重点人才项目(K201103) （K201103）
江苏省人民医院心血管病临床医学中心开放课题(ZX07200907) （ZX07200907）
