青岛大学医学院学报2012，Vol.48Issue(4)：324-326,3.
儿茶素对实验性动脉粥样硬化模型血脂水平影响
EFFECTS OF CATECHIN ON BLOOD FAT LEVEL IN EXPERIMENTAL ATHEROSCLEROSIS MODEL
摘要
Abstract
Objective To study the effects of catechin on hyperlipidemia of experimental atherosclerosis model. Methods This study consisted of 120 male quails, which were randomized to control group, model group, lovastatin (79. 5 mg/kg) group, as well as low-dose 20 mg/kg), medium-dose (40 mg/kg) and high-dose (80 mg/kg) catechin groups. All the quails, except those in the control group, were fed on fat-rich forage. In the end of the sixth week of medication, lipid levels in serum, aorta and cardiac muscle in quails were detected* and the livers were investigated macroscopically and histologically. Results Compared with the model group, the levels of serum triglyceride (TG), total cholesterol (TO , low density lipoprotein cholesterol and apolipoprotein B in each catechin group decreased (F = 5. 45 - 46. 86,q = 2. 00 - 8. 94,P<0. 05), and apolipoproteinA increased (q=3, 25-4. l5,P<0. 05) ; the serum high density lipoprotein cholesterol increased in medium-dose catechin group (q = 2. 38-5. 10,P<0. 05), and, meanwhile, TC and TG in cardiac muscle and TG in aorta markedly decreased (F = 6. 60- 12. 81,q= 2. 47 - 7. 78,P<0, 05), Grading standard of fatty degeneration in each catechin group was lower than that of the model group 9H=42.98,q = 6. 90 - 10. 95, P<0. 05), so did for the liver coefficient (F= 17. 15, q= 3. 00-4. 92, P<0. 05). Conclusion Catechin shows an effect on regulation of blood fat and prevention of atherosclerosis.关键词
儿茶素/动脉粥样硬化/高脂血症/治疗结果/鹌鹑Key words
catechins/ atherosclerosis/ hyperlipidemias/ treatment outcome/ quail分类
临床医学引用本文复制引用
于春刚,李荣运,刘占涛,高华,梁慧,刘坤..儿茶素对实验性动脉粥样硬化模型血脂水平影响[J].青岛大学医学院学报,2012,48(4):324-326,3.基金项目
青岛市科技局支撑计划项目(09-1-1-31-nsh) （09-1-1-31-nsh）
