青岛大学医学院学报2012，Vol.48Issue(4)：330-333,4.
CYP11B2基因多态性与缺血性脑卒中和高血压关系
ASSOCIATION OF CYP11B2 GENE POLYMORPHISM WITH ISCHEMIC STROKE AND HYPERTENSION
闫冠华 1王雁 1郑雪萍 1隋爱华1
作者信息
- 1. 青岛大学医学院附属医院神经内科,山东青岛 266003
- 折叠
摘要
Abstract
Objective To investigate the association of polymorphism of aldosterone synthase gene (CYP11B2) with is-chemic stroke (IS) and hypertension. Methods By using case control study, 332 patients and 250 controls were included in this study. CYP11B2 gene-344T/C polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and the intron 2 conversion polymorphism was genotyped using two separated polymerase chain reaction. Results In IS group, genotype frequencies of -344 T/C polymorphism and T gene were higher than that in the control (x2 = 12. 305111.577 ; P<0. 01), TT genotype might be the independent risk factor of IS. However, no significant association of intron 2 polymorphism with stroke was noted (P>0. 05). Conclusion CYP11B2(-344T/C) polymorphism is associated with ischemic stroke, which is likely to be a risk factor for prediction of ischemic stroke in Chinese Han people, but intron 2 polymorphism is not associated with the disease.关键词
醛固酮合酶/脑血管意外/基因型/基因频率Key words
aldosterone synthase/ cerebrovascular accident/ genotype/ gene frequency分类
临床医学引用本文复制引用
闫冠华,王雁,郑雪萍,隋爱华..CYP11B2基因多态性与缺血性脑卒中和高血压关系[J].青岛大学医学院学报,2012,48(4):330-333,4.
