青岛大学医学院学报2012，Vol.48Issue(4)：355-357,360,4.
牛磺酸对阿尔茨海默病模型大鼠学习记忆能力影响
THE EFFECT OF TAURINE ON CAPABILITY OF LEARNING AND MEMORY IN AIZHEIMER DISEASE MODEL RAT
摘要
Abstract
Objective To investigate the effect of taurine on capability of learning and memory in Alzheimer disease (AD) rats. Methods Eighty-four male SD rats were evenly randomized to control group, sham-operation group, AD model group, positive-control group, high-dose-, moderate-dose- and low-dose-taurine groups. The rats in normal group, sham-operation group and model group were given normal saline; those in positive-control group were given Huperzine A (0.16 mg · kg -1 · d-1) and those in high-dose-, moderate-dose- and low-dose-taurine groups were offered taurine, 600, 400 and 200 mg · kg-1 · d-1, respectively. The medicine in all groups was administered intragastrically. Ten days after medication. 5 μL Aβ1-40 was injected into the right hippocampus of the rats in the three taurine groups, and commensurable phosphate buffered solution (0. 01 mol/L) was injected into the same site of rats in sham-operation group. No treatment was done for the control group. Morris maze experiment was used to test the learning and memory ability, and the levels of acetylcholine ( Ach), acetylcholinesterase (AChE), choline acetyltransterase (ChAT). superoxide dismutase (SOD), malonaldehyde (MDA) and glutathione peroxidase (GSH-Px) in hippocampus were measured. Results Compared wiih the AD model group, the escape latency in positive-control group and the taurine groups was significantly shorter (F=2. 20,q=A. 13 -4. 52,P<0, 05), the times of traversing platform and the swimming time in trie third quadrant increased evidently (F=2. 78,2. 56;q=3. 74 - 4. 38;P<0, 05), the contentof of Ach and the activity of ChAT, SOD. and GSH-Px elevated (F=2. 22-3.38,q=3. 41-4. 25,P<0. 05), The activity of AChE and the content of MDA declined (F=5, 13,5. 04;q=3. 27 - 4. 46;F<0. 05). Conclusion Taurine cati obviously improve the capability of learning and memory in Alzheimer-disease-like model rats, the mechanism is probably associated with the antioxidation of taurine and improv-ment of the function of cholinergic system.关键词
牛磺酸/β淀粉样肽/阿尔茨海默病Key words
taurine/ amyloid beta-peptide/ Alzheimer's disease分类
药学引用本文复制引用
郭艳,王蕾,韩梅,李凤晓,鞠传霞..牛磺酸对阿尔茨海默病模型大鼠学习记忆能力影响[J].青岛大学医学院学报,2012,48(4):355-357,360,4.基金项目
青岛市科技局科研基金资助项目(10-3-3-1-8-NSH) （10-3-3-1-8-NSH）
