四川中医2012，Vol.30Issue(6)：45-48,4.
安胃汤对慢性萎缩性胃炎模型大鼠EGF EGFR mRNA表达的影响
Effect of Anwei Decoction on Expression of EGF、 EGFR mRNA in Rats with Chronic Atrophic Gastritis
摘要
Abstract
Objective: To explore the effect of Anwei Decoction ( AD) on the expression of EGF, EGFR mRNAs in rats with chronic atrophic gastritis (CAG). Methods: Forty eight healthy rats were randomly divided into 4 groups: normal control group, pathologic model group, Anwei Decoction group, and Weifuchun group. CAG was induced in rats with N-methy-N-nitro-N-ni-troguanidine (MNNG). The effects of these medicines on the expressions of EGF, EGFR mRNAs in rats' gastric mucosas were determined by realtime polymerase chain reaction (real-time PCR). Results: Compared with the pathologic model group, the expression of EGF mRNA was remarkably reduced in Anwei Decoction and Weifuchun groups (0.32±0.04 vs 0.64±0.08, 0.42 ±0.05 vs 0.64±0.08, P<0.01). The expression level of EGFR mRNA was significantly lower in Anwei Decoction group than in Weifuchun group (P<0.01). Compared with the pathologic model group, the expression of EGFR mRNA was remarkably reduced in Anwei Decoction and Weifuchun groups (0.56±0. 11 vs 0.78±0.14, 0.67±0.08 vs 0. 78±0.14, P<0.01). The expression level of EGFR mRNA was significantly lower in the Anwei Decoction group than in the Weifuchun group ( P<0.05). Conclusion: Anwei Decoction may treat CAG by reducing the expression of EGF, EGFR mRNA in gastric mucosas.关键词
安胃汤/慢性萎缩性胃炎/EGF/EGFR/实验研究Key words
Anwei/Decoction/atrophic/gastritis/EGF/EGFR/Experimental/research分类
医药卫生引用本文复制引用
朱永苹,林寿宁,韦维..安胃汤对慢性萎缩性胃炎模型大鼠EGF EGFR mRNA表达的影响[J].四川中医,2012,30(6):45-48,4.基金项目
广西中医学院课题(No:P2006032),广西卫生厅课题(No:Z2007131) （No:P2006032）
