四川中医2012，Vol.30Issue(7)：59-61,3.
安子合剂对ACA阳性先兆流产患者CD4+CD25+FOXP3+Treg细胞免疫调节的影响
TheEffect of Anzi Mixture on Immune Regulation of CD4+CD25+FOXP3+Treg Cells in ACA-positive Patients with Threatened Abortion
朱姝 1陆启滨2
作者信息
- 1. 南京中医药大学 江苏 南京 210029
- 2. 江苏省中医院 江苏 南京 210029
- 折叠
摘要
Abstract
Objective; To observe the effect of Anzi Mixture on immune regulation of CD4+CD25+FOXP3+Treg cells in ACA -positive patients with threatened abortion. Methods: Selecting ACA-positive patients with threatened abortion as treatment group (27cases) , 125ml Anzi Mixture were given, 2 times a day, consecutive administrated for 4 weeks; selecting normal pregnant women as the control group ( 15cases). Detecting the percentage of peripheral blood CD4+CD25+FOXP3+Treg cells in the two groups, detecting the indicators of ACA before and after treatment by Anzi Mixture, B-ultrasound embryo development and so on. Results; Before treatment, the proportion of CD4+CD25+FOXP3+Treg cells in ACA-positive patients with threatened abortion was significantly lower than the control group (P<0. 01) ; after treatment of Anzi Mixture, the proportion of CD4+CD25+FOXP3+ Treg cells was significantly higher than before treatment (P<0. 01 ). The ACA negative rate of the qualitative indicators was 85. 00% , 7 cases of quantitative indicators of ACA titers were significantly decreased compared with before treatment ( P < 0.01). Success rate of miscarriage was 92. 59% . Conclusion; CD4+CD25+FOXP3+Treg cells percentage were lower than normal pregnant women in peripheral blood of ACA-positive patients with threatened abortion who exist abnormal immune regulation. One of the mechanisms of Anzi Mixture is to increase the percentage of CD4+CD25+FOXP3+ Treg cells and to regulate the immune function of pregnancy.关键词
抗心磷脂抗体/先兆流产/CD4+CD25+FOXP3+调节性T细胞/安子合剂Key words
ACA/ Threatened abortion/ CD4+CD25+FOXP3+Treg cells/ Anzi Mixture分类
医药卫生引用本文复制引用
朱姝,陆启滨..安子合剂对ACA阳性先兆流产患者CD4+CD25+FOXP3+Treg细胞免疫调节的影响[J].四川中医,2012,30(7):59-61,3.
