生物医学工程研究2012，Vol.31Issue(2)：85-90,6.
可分解食道支架缝合线体外降解性能的研究
Study on in Vitro Degradation of Sutures for Decomposable Esophageal Stent
摘要
Abstract
Poly ( L - lactide) (PLLA) and poly ( glycolide - co - lactide) (PGLA) sutures for decomposable esophageal stent were investigated in phosphate buffer solution (PBS) (pH = 7.4) at 37℃ for period of 8 weeks. The in vitro degradation was studied by determining the change of weight loss, pH value, intrinsic viscosity, tensile strength, orientation degree, degree of crystallinity, melting point and surface morphology of the suture samples. The results showed that all properties of PLLA sutures had no obvious changes in 8 weeks, however, the properties of PGLA sutures all changed significantly. The pH value, intrinsic viscosity, tensile strength, orientation degree and degree of crystallinity decreased gradually, but the weight loss of PGLA sutures increased with the increase of degradation time. At 6th week, tensile strength of PGLA sutures nearly reached zero, and weight loss approached to 70% at 8th week. The results of DSC showed that melting point of crystalline region of PGLA sutures substantially remained unchanged and melting heat enthalpy increased gradually during in vitro degradation, and the new ordered regions appeared in die amorphous area. The results of SEM showed that surface coating of PGLA sutures spoiled initially, and then the sutures oceured transverse rupture. Therefore PGLA suture is suitable to prepare decomposable esophageal stent to expand benign esophageal stenosis or stricture, but stent prepared by PLAA suture is not appropriate for treatment of benign esophageal stenosis because it is decomposed for more than 2 months.关键词
聚(L-丙交酯)/聚(乙交酯-丙交酯)/缝合线/体外降解/可分解食道支架Key words
Poly (L - lactide)/ Poly( glycolide -co - lactide) j Suture/ In vitro degradation/ Decomposable esophageal stent分类
医药卫生引用本文复制引用
王勤,刘吉勇,王传栋,马丽霞,刘阳,李俊起,刘瑾..可分解食道支架缝合线体外降解性能的研究[J].生物医学工程研究,2012,31(2):85-90,6.基金项目
山东省科技发展计划资助项目(2009GG10002077). （2009GG10002077）
