山东中医药大学学报2012，Vol.36Issue(4)：329-333,5.
黄连解毒汤使药对臣-佐药干预热病证候模型生物标志物的影响
Effects of adding courier medicinal to minister-assistant medicinal in Huanglian Jiedu decoction on the biological markers of fever syndrome model
摘要
Abstract
Objective;To explore the biomarker effect of courier medicinal Gardenia Jasminoides Ellis on minister-assistant medicinal Scutellaria Baicalensis-Cortex Phellodendri in Huanglian Jiedu decoction intervention fever syndrome model induced by 2,4-dinitrophenoL Methods: According to the metabolomics, PC A and OPLS-DA analysis methods were utilized to study the change rules of the potential biomarker in rats urine of fever syndrome model, comforming the impact of Scutellaria Baicalensis-Cortex Phellodendri and Scutellaria Baicalensis-Cortex Phelloden-dri-Gardenia Jasminoides Ellis. Results: Confirming the overall change of urinary metabolites and 46 potential endogenous biomarkers on fever syndrome models. Scutellaria Baicalensis-Cortex Phellodendri have effected on 21 biomarkers and Scutellaria Baicalensis-Cortex Phellodendri-Gardenia Jasminoides Ellis have effected on 24 biomarkers. Conclusion: Courier medicinal Gardenia Jasminoides can strengthen the role of minister-assistant medicinal Scutellaria Baicalensis-Gortex Phellodendri on fever syndrome model.关键词
黄连解毒汤/2,4-二硝基苯酚/代谢组学/热病证候模型/生物标志物/大鼠Key words
Huanglian Jiedu decoction/2,4-dinitrophenol/metabonomics/fever syndrome model/biomarker/rat分类
医药卫生引用本文复制引用
祖金祥,方圆,刘树民..黄连解毒汤使药对臣-佐药干预热病证候模型生物标志物的影响[J].山东中医药大学学报,2012,36(4):329-333,5.基金项目
国家重点基础研究发展计划(973计划)(编号:2007CB512608) （973计划）
