山东中医药大学学报2012，Vol.36Issue(4)：338-340,3.
安神定志灵对ADHD模型鼠血清多巴胺及S100β蛋白的影响
Effects of Anshen Dingzhiling pills on serum dopamine and protein S100β of rats with attention deficit hyperactivity disorder
摘要
Abstract
Objective:To explore the effects of Anshen Dingzhiling pills(ASDZLP) on serum dopamine(DA) and neurotrophic factor protein S100β(protein S100P) of spontaneously hypertensive rats(SHR) with attention deficit hy-peractivity disorder (ADHD). Methods: Total 30 SHR rats were randomly divided into five groups; the model group, methylphenidate group (treated by litalin), low-dose ASDZLP group, medium-dose ASDZLP group, and high-dose ASDZLP group. There were 6 rats in each group. Meanwhile,6 WKY rats were set as the normal control group. After given drugs two weeks,the contents of serum DA and protein SlOOp were detected by ELISA and BCA methods. Results;Compared with normal control group,serum levels of DA and protein SlOOp of model group were significantly decreased (P<0.05). Compared with model group,serum levels of DA and protein SlOOp of the methylphenidate group and ASDZLP groups were increased(P<0.05). Conclusion;The DA and the protein SlOOp maybe the effective targets of Anshen Dingzhiling pills in treating ADHD.关键词
安神定志灵/注意力缺陷多动障碍/多巴胺/神经营养因子S100β蛋白/自发性高血压大鼠Key words
Anshen Dingzhiling pills/ attention deficit hyperactivity disorder/ dopamine/ neurotrophic factor protein SlOOβ/spontaneously hypertensive rats分类
医药卫生引用本文复制引用
李亚群,韩新民,倪新强,尹东奇..安神定志灵对ADHD模型鼠血清多巴胺及S100β蛋白的影响[J].山东中医药大学学报,2012,36(4):338-340,3.基金项目
教育部高等学校博士学科点专项科研基金(编号:200803150003) （编号:200803150003）
