山东医药2012，Vol.52Issue(21)：1-3,3.
RRM1和ERCC1在非小细胞肺癌中的表达及意义
Expression and prognostic significance of ERCC1 and RRM1 in non-small cell lung cancer
摘要
Abstract
Objective To investigate the expressions of ERCC1 and RRM1 in patients with non-small cell lung cancer ( NSCLC) as well as their clinical prognostic significance. Methods ERCC1 and RRM1 in 30 cases of ⅢB/IV non-small cell cancer were detected by PV-9000 immunohistochemistry. The chi-square test, Fishers test, rank correlation, Kaplan-Meier survival curve were used for statistical analysis. Results There was no significant difference between the RRM1 or ERCC1 expression and sex, age, pathological type or TNM stage (all P >0. 05). There was a positive correlation between ERCC1 and RRM1 expressions (P =0.015). The ERCC1 negative group on overall survival and progression-free survival time were significantly longer than those in positive group, the RRM1 negative group on overall survival and progression-free survival time were significantly longer than those in positive group. Conclusions There was a correlation between ERCC1 and RRM1 expression in NSCLC. The lower expression of ERCC1 and RRM1 were related with the longer survival time- and quality-dependent mode. The expressions of ERCC1 and RRM1 can be predicted with gemcitabine for advanced non-small cell lung cancer effects of chemotherapy. Chemotherapy can be used as the selection of individual chemotherapy at the time of reference.关键词
癌/非小细胞肺/DNA修复酶类/预后/ERCC1/RRM1Key words
carcinoma, non-small-cell lung/ DNA repair enzymes/ prognosis/ ERCC1/ RRM1分类
医药卫生引用本文复制引用
胡跃云,张献波,董英辉,乞国艳,张燕,刘津来..RRM1和ERCC1在非小细胞肺癌中的表达及意义[J].山东医药,2012,52(21):1-3,3.基金项目
河北省科技支撑计划项目(09276121). （09276121）
