山东医药2012，Vol.52Issue(21)：4-7,4.
鲍曼不动杆菌临床株中可移动遗传元件ISCR1的作用
Effect of ISCR1 in clinical isolates of Acinetobacter baumannii
摘要
Abstract
Objective To study the distribution of novel mobile genetic element ISCR1 and the genes related to antibiotics resistance located downstream of ISCR1 among 55 clinical isolates of Acinetobacter baumannii, to disscuss the dissemination mechanism of antibiotics resistance in Acinetobacter baumannii. Methods 34 multidrug resistant Acinetobacter baumannii islates and 21 sensitive isolates were collected. ISCR1 gene and the genes related to antibiotics resistance located downstream of ISCR1 were amplified by PCR and analysed by DNA sequencing. Results Among 34 multidrug resistant Acinetobacter baumannii isolates, ISCR1 gene were carried in 14 MDR isolates and armA gene related to resistance of ami-noglycosides were located downstream of ISCR1 element in 11 MDR isolates. ISCR1 element were not carried in all of the 21 sensitive. Conclusion ISCR1 element may play a role in the dissemination of armA gene related to resistance of amin-oglycosides.关键词
鲍曼不动杆菌/ISCR1/armA基因/可移动遗传元件Key words
acinetobacter baumannii/ ISCR1/ armA gene/ mobile genetic element分类
医药卫生引用本文复制引用
王悦,宋诗铎,吴晓妹,张利娟..鲍曼不动杆菌临床株中可移动遗传元件ISCR1的作用[J].山东医药,2012,52(21):4-7,4.基金项目
天津医科大学科学基金(2009XK26). （2009XK26）
