山东医药2012，Vol.52Issue(21)：33-35,3.
康复训练对脑缺血大鼠行为学及BDNF、CaBP-D28k表达的影响
Effects of rehabilitation training on the neurological behavior and the expression of BDNF,CaBP-D28k for focal cerebral ischemia of rats
摘要
Abstract
Objective To investage the effect of rehabilitation training on the neurological behavior and the expressions of BDNF, CaBP-D28k for focal cerebral ischemia of rats. Methods Left middle cerebral artery occlusion was induced by an intraluminal lament. SD rats were randomly divided into 3 groups: sham-exercise group ( SE) , ischaemia-con-trol group (IC) , and ischaemia-exercise group (IE). IE groups were treated with rehabilitation training after the induction of ischaemia for 24 hours,but SE and IC groups were short of intervention. Bederson test was carried out and the expressions of BDNF, CaBP-D28k around the infarct were detected at 3,7 and 14 days after the induction of ischaemia. Results Neurological behavioral score of SE group was 0, and there was short of difference on neurological behavioral score in IC and IE group at 3 days after the induction of ischaemia ( P > 0. 05) , but which was significantly lower in IE group than that in IC group at 7 and 14 d (all P < 0.01). The expressions of BDNF and CaBP-D28k in cerebral ischemia were no difference among the three groups at 3 d, but they increased in IE group as compared with the SE and IC groups at 7 and 14 d (all P<0.01). Conclusion Rehabilitation training plays a neuroprotective role in promoting the expressions of BDNF and CaBP-D28K.关键词
脑缺血/康复训练/神经行为学评分/脑源性神经营养因子/钙结合蛋白-D28k/大鼠Key words
brain ischemia/ rehabilitation training/ neurological behavioral score/ BDNF/ CaBP-D28k/ rats分类
医药卫生引用本文复制引用
白蓉,梁雪琴,王魁花..康复训练对脑缺血大鼠行为学及BDNF、CaBP-D28k表达的影响[J].山东医药,2012,52(21):33-35,3.基金项目
国家医学教育发展中心课题项目(2010-16-00-191). （2010-16-00-191）
