山东医药2012，Vol.52Issue(22)：12-14,3.
活化增视冲剂对PVR防治作用的机制探讨
Inhibition effect of Huohuazengshi medicinalgranules on proliferative vitreoretinopathy
摘要
Abstract
Objuctive To study the curative and preventive effects and the mechanism of huohuazengshi (HHZS) medicinalgranules on proliferative vitreoretinopathy (PVR) in rabbits. Methods 60 rabbits (120 eyes) were randomly divided into HHZS group( A group). Control group( B group) and blank group(C group) , 20 rabbits(40 eyes) each group. Experimental PVR models were induced by injecting macrophage into vitreous, the formation and development of PVR was observed by indirect ophthalmoscope, the content of IL-lβ and TNF-α from the vitreous were determined. Results Compared with B group, the content of IL-lβ and TNF-α in A group was decreased in 7 days(P<0.05) and decreased significantly in 14,21 and 28 d (P<0.01). The incidence of PVR above 2 grades in 14,21 and 28 daya was lower than B group (P<0.05). Conclusions HHZS medicinalgranules can inhibit and cure the formation and development of PVR by decreasing the content of IL-1 (1 and TNF-a in vitreous and inhibiting cell proliferation and migration.关键词
增殖性玻璃体视网膜病变/活化增视冲剂/白细胞介素/肿瘤坏死因子Key words
proliferative vitreoretinopathy/ Huohuazengshi medicinalgranules/ interleukine 1β/ tumor necrosis factor α分类
医药卫生引用本文复制引用
郝延蕾,高薇,原越,于海群,李志红..活化增视冲剂对PVR防治作用的机制探讨[J].山东医药,2012,52(22):12-14,3.基金项目
山东省自然科学基金资助项目(Y2007C129). （Y2007C129）
