山东医药2012，Vol.52Issue(24)：10-12,15,4.
CD147、EBP1 mRNA在新疆哈萨克族和汉族食管鳞癌中的表达及意义
Expression and significance of CD147, EBP1 mRNA in esophageal squamouscell carcinoma of Kazak and Han nationality in Xinjiang
摘要
Abstract
Objective To investigate the expression and clinical significance of CD147, EBP1 mRNA in esophageal sqamous cell carcinoma (ESCC) of Kazak and Han nationality in Xinjiang. Methods RT-PCR method was used to detect the expression of CD147, EBP1 mRNA in 77 samples of ESCC tissues and distantnon-carcinomatous esophageal tissues. Results The expression level of CD147 in ESCC tissues and distantnon-carcinoma tissues was 0.883 ± 0.040 and 0.675 ± 0.023 (P=0.013). The expression level of EBP1 was 0.574 ± 0.039 and 0.797 ±0.035, respectively (P=0.022). The positive expression rate of CD147 in Han and Kazak nationality was 77. 5% and 81. 0% (P = 0. 497 ) , EBP1 was 82.5% and 78.4% (P = 0.236), respectively. The positive rate of CD147 expression was significantly higher in esophageal carcinoma than that in distant non-carcinoma tissue (79.2% vs49.3% , P = 0.003). There was significant difference in the positive rate of EBP1 expression between carcinoma and non-carcinoma tissue (61.0% vs 84.4% , P = 0.005 ). The expression of CD147 was correlated with the depth of invasion, lymph node metastasis in esophageal carcinoma (P < 0.05); there was a significant correlation between the expression of EBP1 mRNA and the tumor stage, lymphatic metastasis ( P < 0.05). CD147 expression was negatively correlated with EBP1 expression. Conclusions CD147 and EBP1 expression in ESCC were no difference between Kazak and Han nationality. High expression of CD147 and low expression of EBP1 might promote the carcinogenesis and metastasis of esophgeal carcinoma.关键词
食管肿瘤/鳞状细胞癌/CD147/EBP1Key words
esophageal neoplasms/ carcinoma squamous cell/ CD147/ EBP1分类
医药卫生引用本文复制引用
魏智勇,李卉,庞作良,李惠武,王洪江..CD147、EBP1 mRNA在新疆哈萨克族和汉族食管鳞癌中的表达及意义[J].山东医药,2012,52(24):10-12,15,4.基金项目
国家自然科学基金资助项目(81160271). （81160271）
