山东医药2012，Vol.52Issue(27)：23-25,3.
VEGF-C和VEGFR3在细支气管肺泡癌组织中的表达及意义
Expression and significance of VEGF-C and VEGFR3 in bronchioalveolar carcinoma
摘要
Abstract
Objective To investigate the roles of vascular endothelial growth factor(VECF)-C and its receptor VEG-FR3 in the formation and progression of bronchioalveoiar carcinoma! BAC). Methods Sixty cases of BAC excissed From patients were enrolled in BAC group, control group were 10 cases of lung tissue adjacent to BAC. Expression of VEGF-C and VECFR3 were detected by using immunohistochemicall. Lymphatic vessels were identified by D2-40 to caculate lym-phaticmicrovessel density(LVD). Relationship between each index and their relationships with clinicopathologic parameters were analyzed. Results Positive rate of VEGF-C, VEGFR3 and LVD in BAC group was all notably higher than those in control group (/><0.01) ; poslive rate of VEGF-C in nonmucinous cases was notably higher than that in mucinous cases ( P < 0.01), postive rate of VEGF-C in cases with node metastasis was obviously higher than that in cases without node me-lasiases (P < 0.05 ) , positve rate of VEGFR3 in node metastasis was obviously higher than that in eases without node metas-tases(P<0.05). LVD in node metastasis was obviously higher than that in cases without node metastases(P < 0. 05); there was a positive correlation among VEGF-C,VEGFR3 and LVD(P <0.05). Conclusion There is a synergistic effect between VEGF-C and VEGFR3 in promoting lymphangiogenesis and lymph node metastasis in BAC. By blocking the signal transduction pathway is expected to be a new target of anti-lymph node metastasis in BAC.关键词
细支气管肺泡癌/血管内皮生长因子-C/血管内皮生长因子受体/微淋巴管密度/淋巴结转移Key words
bronchioalveoiar carcinoma/ vascular endothelial growth factor-C/ vascular endothelial growth factor R3 j lymphaticmicrovessel density/ metastasis分类
医药卫生引用本文复制引用
邹亮,高慧淳,欧阳莉,朱敏媛,刘文,周建洪..VEGF-C和VEGFR3在细支气管肺泡癌组织中的表达及意义[J].山东医药,2012,52(27):23-25,3.基金项目
江西省科技厅支撑计划项目(项目编号:2009BSB11108). （项目编号:2009BSB11108）
