山东医药2012，Vol.52Issue(28)：10-12,后插1,4.
清胰Ⅱ号颗粒剂对大鼠重症急性胰腺炎合并肾损伤时的保护作用
Changes of acute renal injury in SAP rats and the protective function of QingYi Ⅱ
摘要
Abstract
Objective To observe the effects and explore the mechanism of the traditional Chinese medicine QingYi Ⅱ for severe acute pancreatitis (SAP) complicated with acute renal injury ( ARI). Methods 48 healthy SD rats were randomly divided into three groups; sham operation group (group A,re = 16) .SAP model group (group B,n = 16) and QingYi Ⅱ group (group C,n = 16). The model of SAP was induced by retrograde injection of 3% sodium taurocholate into bilio-pancreatic duct in group B, C, while group A were only flipped the intestinal canal; after one hour, group A, B were fed with saline, QingYi Ⅱ was fed to rats in group C. All rats were sacrificed after SAP had been produced for 12 hours and 24 hours, the blood was drawn from portal vein. The concentrations of serumamy-amylase, ureanitro-gen, creatinine and the expression of renal tissue TNF-α mRNA were measured. Pathologic change of kidney and pancreas were observed under microscope. Results The concentrations of serumamylase, urea nitrogen, creatinine, the expression of renal tissue TNF-αmRNA were higher in group B than those in group A (P < 0.05 ). The concentrations of serumamylase, urea nitrogen, creatinine, the expression of renal tissue TNF-αmRNA were lower in group C than those in group B ( P < 0. 05 ). Group B had serious pathologic damage in both pancrea and kidney, more ascites and sapon spot. Group C had less pathologic damage in both pancrea and kidney, more ascites and sapon spot. Conclusion The traditional Chinese medicine QingYi Ⅱ may play an important role in treating SAP complicated with ARI.关键词
重症急性胰腺炎/急性肾损伤/清胰Ⅱ号颗粒剂Key words
severe acute pancreatitis/ acute renal injury/ traditional Chinese medicine QingYi E分类
医药卫生引用本文复制引用
蔡治方,兑丹华,陈正修,兰天罡..清胰Ⅱ号颗粒剂对大鼠重症急性胰腺炎合并肾损伤时的保护作用[J].山东医药,2012,52(28):10-12,后插1,4.基金项目
贵州省科技厅中医药现代化攻关项目[黔科合中药专字(2003)13号]. （2003）
