山东医药2012，Vol.52Issue(31)：1-3,3.
非小细胞肺癌组织中Th17及CD4+CD25+Treg细胞的表达及意义
Expression and signification of Th17 and CD4 + CD25 + regulatory T cells in nonsmall cell lung cancer tissue
摘要
Abstract
Objective To investigate the expression and signification of Thl7 and CD4+ CD25 + regulatory T cells (Treg, with the marker of CD4, FoxP3, IL47A) in nonsmall cell lung cancer (NSCLC) tissue. Methods The expression patterns of IL-17 A and FoxP3 in tissues of 102 NSCLC patients were detected by immunohistochemistry , with tissues from adjacent noncancerous tissues as control, then the relationship between expression patterns of CD4, FoxP3, IL-17A and clinicopathological factors were analyzed. Results The positive rates of CD4, FoxP3 and IL-17A in NSCLC were significantly higher than those in the adjacent noncancerous tissues(P <0.05). The expression of IL-17A was related to the sex of patients, the expression of CD4, FoxP3 were related to the histological grade of NSCLC. Conclusions The population of CD4 + CD25 + Treg and Thl7 cells from the patients with NSCLC is significantly high; CD4 + CD25 + Treg and Thl7 cells may have high chemotaxis and easily be enriched to the tumor tissue, so as to play inhibitory roles.关键词
Th17辅助细胞/CD4+CD25+Treg细胞/非小细胞肺癌Key words
T17 helper cell/ CD4+ CD25 + regulatory T cells/ non-small cell lung cancer分类
医药卫生引用本文复制引用
马晓梅,张银华,王晓璐,房新志,赵峰,张焕,张国庆..非小细胞肺癌组织中Th17及CD4+CD25+Treg细胞的表达及意义[J].山东医药,2012,52(31):1-3,3.基金项目
国家自然科学基金资助项目(No.30960441) （No.30960441）
