同济大学学报（医学版）2012，Vol.33Issue(3)：58-63,6.DOI:10.3969/j.issn1008-0392.2012.03.014
131I治疗分化型甲状腺癌肺转移疗效及影响因素的研究
Efficacy and influencing factors of 131I therapy for lung metastases of differentiated thyroid carcinoma: a retrospective study
刘媛媛 1潘明志2
作者信息
- 1. 同济大学附属第十人民医院超声科,上海200072
- 2. 四川大学华西医院核医学科,成都610041
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and influencing factors of 131Ⅰ therapy for lung metastases of differentiated thyroid carcinoma ( DTC). Methods Forty eight patients with lung metastases of DTC who received 131Ⅰ treatment in Department of Nuclear Medicine of West China Hospital from September 2004 to March 2007 were retrospectively reviewed. The efficacy and influencing factors of 131Ⅰ therapy was evaluated with univariate and multivariate analysis. Results In 48 cases with lung metastases of DTC, the complete remission rate of 131Ⅰ therapy was 10.4% , the response rate was 62. 5% and no response rate was 37. 5%. Univariate logistic regression analysis showed that the age, chest X-Ray or CT findings, distant metastases other than lung, serum thyroglobulin levels at diagnosis and lung 131Ⅰ uptake rate were factors influencing outcome of 131Ⅰ therapy; sex, histology, cervical lymph node metastases and thyroid remnants had no influence on efficacy. Multivariate logistic regression analysis showed that distant metastases other than lung, serum thyroglobulin levels at diagnosis and lung 131Ⅰ uptake rate were the influencing factors. Conclusion 131Ⅰ therapy is an effective and safe method for lung metastases of DTC and some factors would influence the efficacy of the therapy.关键词
分化型甲状腺肿瘤/肺转移/131碘Key words
differentiated thyroid carcinoma/ lung metastases/131?分类
医药卫生引用本文复制引用
刘媛媛,潘明志..131I治疗分化型甲状腺癌肺转移疗效及影响因素的研究[J].同济大学学报（医学版）,2012,33(3):58-63,6.
