同济大学学报（医学版）2012，Vol.33Issue(4)：46-48,62,4.DOI:10.3969/j.issn1008-0392.2012.04.010
特发性血小板减少性紫癜血小板生成素的测定及其临床意义
Serum thrombopoietin levels in patients with idiopathic thrombocytopenic purpura and its significance
高青梅 1梁爱斌1
作者信息
- 1. 同济大学附属同济医院血液科,上海200065
- 折叠
摘要
Abstract
Objective To investigate serum thrombopoietin (TPO) levels in patients with idiopathic thrombocytopenic purpura (ITP) and its significance. Methods The serum levels of thrombopoietin in ITP patients (n - 45) and healthy subjects (control group, n - 25) were tested by sandwich enzyme-linked immunosorbent assay. The peripheral platelet counts were measured by automatic hemocyte analyzer; and the bone marrow megakaryocytes were counted directly under microscope. Among 45 ITP patients, 37 were responders and 8 were non-responders to treatment. Results The counts of platelets in ITP patients significantly decreased (P<0.05); and the counts of megakaryocytes increased (P<0.05). However, there was no significantly difference in serum TPO levels between ITP patients and control group. The TPO levels of responder ITP patients were significantly higher than those of non-responders and healthy controls (P <0.05); The megakaryocyte counts of non-responder patients were significantly lower than that of patients in responders (P<0.05). Conclusion The serum levels of thrombopoietin may be a useful indicator for
effectiveness of treatment.关键词
特发性血小板减少性紫癜/血小板生成素/疗效Key words
Purpura/ thrombocytopenic/ idiopathic/ Thrombopoietin/ Curative result分类
医药卫生引用本文复制引用
高青梅,梁爱斌..特发性血小板减少性紫癜血小板生成素的测定及其临床意义[J].同济大学学报（医学版）,2012,33(4):46-48,62,4.
