山西医科大学学报2012，Vol.43Issue(7)：509-511,3.DOI:10.3969/J.ISSN.1007-6611.2012.07.008
不同病程2型糖尿病患者内皮依赖性血管舒张功能的变化
Change of endothelial dependent vasodilation in patients with different courses of type 2 diabetes
杜艳 1杜玲 1王永丰 1李贞艳 1徐黎鸣 1文莉 1韩瑛1
作者信息
- 1. 湖北医药学院附属太和医院中心供应室,十堰442000
- 折叠
摘要
Abstract
Objective To investigate the changes of endothelial dependent dilation (FMD) in the different disease course patients with type 2 diabetes, and the relationship between FMD and fasting plasma glucose, glycosylated serum protein. Methods One hundred patients with T2 DM were collected and divided into 3 groups according to the duration of the disease: < 1 year group (n=37),l -5 years group ( n = 33 ), 5-10 years group (n = 33). Forty normal controls with matched age and sex were chosen as control group. All subjects underwent high frequency ultrasound to detect the brachial artery FMD. Fasting plasma glucose( FPG) .glycosylated serum protein (GA) ,triglyceride (TG) , cholesterol (TC ), low density lipoprotein ( LDL-C ), fasting insulin levek and other metabolic markers were simultaneously detected,and the insulin resistance index (HOMA-IR) was calculated. Results Compared with NC group,FMD decreased significantly in T2DM group(P<0.01) .while GA,FPG,HOMA-IR,TG,TC,LDL levels increased significantly (P<0.05). FPG,HOMA-IR,GA,TG,TC,LDL in 1 -5 years group and 5-10 years group were significantly higher than those in < 1 year group (P < 0.05), but there was no significant difference between 1-5 years group and 5-10 years group( P > 0.05 ). Conclusion The endothelium-dependent dilation(FMD)significantly decreases in type 2 diabetes patients,and with the extension of the disease duration, vascular endothelial function reduces gradually, which suggests that FMD is more susceptible to develop the diabetic vascular diseases.关键词
2型糖尿病/内皮依赖性血管舒张功能/病程Key words
type 2 diabetes/ endothelial dependent dilation/ disease course分类
医药卫生引用本文复制引用
杜艳,杜玲,王永丰,李贞艳,徐黎鸣,文莉,韩瑛..不同病程2型糖尿病患者内皮依赖性血管舒张功能的变化[J].山西医科大学学报,2012,43(7):509-511,3.
