山西医科大学学报2012，Vol.43Issue(7)：544-547,4.DOI:10.3969/J.ISSN.1007-6611.2012.07.020
纳美芬对开胸手术患者术后呼吸抑制的拮抗作用
Antagonistic effect of nalmefene on postoperative respiratory depression in patients after thoracic surgery
雷晓鸣 1张珍妮 1钞海莲 1吕建瑞 1吴刚 1李芳1
作者信息
- 1. 西安交通大学医学院二附属医院麻醉科,西安710004
- 折叠
摘要
Abstract
Objective To explore the effect of nalmefene on the postoperative respiratory depression in patients after the thoracic surgery. Methods Seventy-two patients undergoing thoracic surgery were divided into 3 groups according to the drugs after surgery. The patients in naloxon group and nalmefene group were injected intravenously with naloxone (1 μg/kg) and nalmefene (0. 25 μg/kg) 5 min after operation,respectively,while patients were not given drugs in control group. Blood pressure( BP),heart rate( HR) .pulse oxygen saturation (SpO2) before and after administration, respiratory recovery rate in 10 min after administration, extubation time, Ramsay sedation score at 5 min after extubation,visual analogue score (VAS) at 30 min after extubation and adverse effects were observed. Results No significant difference was detected in BP,HR,SpO2 before and after administration among three groups(P >0.05). Respiratory recovery rates in 10 min after administration in naloxon group and nalmefene group were higher than that in control group (P <0.05) , and extubation time in naloxon group and nalmefene group was shorter than that in control group (P <0.05),hut there was no significant difference between naloxon group and nalmefene group (P>0.05). No significant difference was detected in Ramsay sedation score, visual analogue score and incidence of adverse effects among three groups (P>0.05). Conclusion Nalmefene is effective and safe for antagonizing the postoperative respiratory depression in thoracic surgery patients. The efficacy is equal to naloxone.关键词
纳美芬/纳洛酮/呼吸抑制Key words
nalmefene/ naloxone/ respiratory depression分类
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雷晓鸣,张珍妮,钞海莲,吕建瑞,吴刚,李芳..纳美芬对开胸手术患者术后呼吸抑制的拮抗作用[J].山西医科大学学报,2012,43(7):544-547,4.
