现代检验医学杂志2012，Vol.27Issue(2)：15-18,4.DOI:10.3969/j.issn.1671-7414.2012.02.005
载脂蛋白A5基因多态性与血脂代谢及冠心病关联研究
Association Study on Apolipoprotein A5 Gene Polymorphism and Serum Lipid Metabolism and Coronary Heart Disease
贺军 1苟志平 1戴江红 1孙勇1
作者信息
- 1. 新疆克拉玛依市中心医院心血管内科,新疆克拉玛依834000
- 折叠
摘要
Abstract
Objective To study of apolipoprotein A5 (ApoA5)-1131 T＞C,1259 T＞C and c. 553G＞T gene polymorphism with lipid metabolism and coronary heart disease (CHD) relationship. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was detected in 54 cases of CHD patients and 58 healthy populations of ApoA5 polymorphism genotype and allele distributions, ApoA5 genotype and CHD of Mood lipid levels in patients with relationship. Results In two groups of ApoA5 genotype and allele frequency differences. And concluded: ①ApoA5-1131 T>C and total cholesterol (CHOL) level, (TC+CC) than TT CHOL level high. ②ApoA5 1259 T>C and high density lipoprotein cholesterol (HDL-C) level, (CT+TT) than CC HDL-C level high. ③The ApoA5 c. 553OT and triglyceride (TG) levels,GT+ TT than type GG TG level high. Conclusion ApoA5 gene polymorphism with lipid metabolism and the incidence of CHD have a certain correlation (P<0. 05).关键词
血脂/载脂蛋白A5/血脂/冠心病/基因多态性Key words
blood lipid/apolipoprotein A5iblood lipid/coronary heart disease/gene polymorphism分类
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贺军,苟志平,戴江红,孙勇..载脂蛋白A5基因多态性与血脂代谢及冠心病关联研究[J].现代检验医学杂志,2012,27(2):15-18,4.
